{"id":190,"date":"2025-04-01T10:26:54","date_gmt":"2025-04-01T02:26:54","guid":{"rendered":"http:\/\/ne6531fr115.vicp.fun\/wordpress\/?p=190"},"modified":"2025-04-01T10:28:56","modified_gmt":"2025-04-01T02:28:56","slug":"25-6%e6%9c%88%e6%9c%9f%e5%88%8a%e9%a2%84%e5%8f%91%e8%a1%a8%ef%bc%9a%e5%ae%9a%e4%b9%89-sars-cov-2-%e8%bf%9b%e5%85%a5%e6%89%80%e6%b6%89%e5%8f%8a%e7%9a%84%e5%90%84%e7%a7%8d%e5%88%ba%e7%aa%81-%e5%8f%97","status":"publish","type":"post","link":"https:\/\/www.12099.icu\/wordpress\/2025\/04\/01\/25-6%e6%9c%88%e6%9c%9f%e5%88%8a%e9%a2%84%e5%8f%91%e8%a1%a8%ef%bc%9a%e5%ae%9a%e4%b9%89-sars-cov-2-%e8%bf%9b%e5%85%a5%e6%89%80%e6%b6%89%e5%8f%8a%e7%9a%84%e5%90%84%e7%a7%8d%e5%88%ba%e7%aa%81-%e5%8f%97\/","title":{"rendered":"25.6\u6708\u671f\u520a\u9884\u53d1\u8868\uff1a\u5b9a\u4e49 SARS-CoV-2 \u8fdb\u5165\u6240\u6d89\u53ca\u7684\u5404\u79cd\u523a\u7a81-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff1a\u673a\u5236\u548c\u6cbb\u7597\u673a\u4f1a"},"content":{"rendered":"\n

6. \u7ed3\u8bba\u548c\u89c2\u70b9<\/h2>\n\n\n\n

SARS-CoV-2 \u4ecd\u7136\u662f\u4e00\u4e2a\u91cd\u5927\u7684\u5168\u7403\u6311\u6218\uff0c\u7ed9\u7ecf\u6d4e\u5e26\u6765\u538b\u529b\uff0c\u5e76\u5bf9\u516c\u5171\u536b\u751f\u6784\u6210\u6301\u7eed\u5a01\u80c1\u3002\u672c\u7efc\u8ff0\u7684\u91cd\u70b9\u662f\u68c0\u67e5\u4e0e SARS-CoV-2 \u523a\u7a81\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7684 ACE2 \u4ee5\u5916\u7684\u9644\u7740\u56e0\u5b50\u548c\u66ff\u4ee3\u53d7\u4f53\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u8ba8\u8bba\u4e86\u5f53\u524d\u65e8\u5728\u51cf\u5c11\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u548c\u9650\u5236\u611f\u67d3\u7684\u6cbb\u7597\u7b56\u7565\u3002SARS-CoV-2 \u5e7f\u6cdb\u7684\u7ec4\u7ec7\u548c\u7ec6\u80de\u55dc\u6027\u53ef\u80fd\u662f\u7531\u4e8e\u5b83\u80fd\u591f\u5229\u7528\u9644\u7740\u56e0\u5b50\u548c\u66ff\u4ee3\u53d7\u4f53\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u8fd9\u4e3a\u672a\u6765\u7684\u7814\u7a76\u5f00\u8f9f\u4e86\u6709\u5e0c\u671b\u7684\u9014\u5f84\u3002\u9996\u5148\uff0c\u8fdb\u884c\u8bf1\u53d8\u548c\u7ed3\u6784\u7814\u7a76\u53ef\u4ee5\u63ed\u793a\u6765\u81ea SARS-CoV-2 \u53d8\u4f53\u7684\u523a\u7a81\u86cb\u767d\u662f\u5426\u5bf9\u9644\u7740\u56e0\u5b50\u6216\u66ff\u4ee3\u53d7\u4f53\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u3002\u53cd\u8fc7\u6765\uff0c\u8fd9\u53ef\u4ee5\u4e3a\u9a71\u52a8 SARS-CoV-2 \u4f20\u64ad\u548c\u53d1\u75c5\u673a\u5236\u7684\u673a\u5236\u63d0\u4f9b\u5173\u952e\u89c1\u89e3\u3002\u5176\u6b21\uff0c\u672a\u6765\u5bf9 SARS-CoV-2 \u8fdb\u5165\u673a\u5236\u7684\u7814\u7a76\u5e94\u8003\u8651\u975e ACE2 \u53d7\u4f53\u7684\u4f5c\u7528\uff0c\u7ed3\u5408\u68c0\u6d4b\u7ec6\u80de\u8868\u9762\u86cb\u767d\u7684\u65b9\u6cd5\u3002\u7b2c\u4e09\uff0c\u8c03\u67e5\u4e0d\u540c\u79cd\u65cf\u6216\u6c11\u65cf\u4eba\u7fa4\u4e4b\u95f4\u662f\u5426\u5b58\u5728\u975e ACE2 \u9644\u7740\u56e0\u5b50\/\u66ff\u4ee3\u53d7\u4f53\u8868\u8fbe\u7684\u53d8\u5f02\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u5dee\u5f02\u5982\u4f55\u5f71\u54cd\u5bf9\u611f\u67d3\u7684\u6613\u611f\u6027\uff0c\u5c06\u662f\u4e00\u4e2a\u6709\u4ef7\u503c\u7684\u7814\u7a76\u9886\u57df\u3002\u6700\u540e\uff0c\u5e94\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4f30\u9776\u5411\u975e ACE2 \u7ec6\u80de\u53d7\u4f53\u548c\u5206\u5b50\u7684\u6f5c\u5728\u76ca\u5904\u548c\u98ce\u9669\u3002<\/p>\n\n\n\n

3. SARS-CoV-2 \u8fdb\u5165\uff1a\u66ff\u4ee3\u53d7\u4f53\uff08ACE2 \u975e\u4f9d\u8d56\u6027\uff09<\/h2>\n\n\n\n

\u6211\u4eec\u5c06\u201c\u66ff\u4ee3\u53d7\u4f53\u201d\u5b9a\u4e49\u4e3a\u5728\u6ca1\u6709 ACE2 \u8868\u9762\u8868\u8fbe\u7684\u60c5\u51b5\u4e0b\u4ecb\u5bfc SARS-CoV-2 \u8fdb\u5165\u7684\u7ec6\u80de\u86cb\u767d\u3002\u5728\u672c\u8282\u4e2d\uff0c\u6211\u4eec\u68c0\u67e5\u6ee1\u8db3\u8fd9\u4e9b\u6807\u51c6\u7684\u86cb\u767d\u8d28\uff0c\u5e76\u6309\u5176\u7ec4\u7ec7\u6216\u7ec6\u80de\u8868\u8fbe\u5bf9\u5b83\u4eec\u8fdb\u884c\u5206\u7ec4\u3002\u8fd9\u5305\u62ec TfR\u3001CD147\u3001ASGR1\/KREMEN1\u3001AXL \u548c TMEM106B\uff08\u8868 2<\/a>;\u56fe 2<\/a>B).<\/p>\n\n\n\n

3.1. \u8f6c\u94c1\u86cb\u767d\u53d7\u4f53 \uff08TfR\uff09<\/h3>\n\n\n\n

\u8f6c\u94c1\u86cb\u767d\u53d7\u4f53 \uff08TfR\uff09 \u4ecb\u5bfc\u94c1\u7684\u6444\u53d6\u548c\u8fd0\u8f93\uff0c\u5e76\u5728\u4eba\u4f53\u4e2d\u666e\u904d\u8868\u8fbe \uff08Wessling-Resnick\uff0c 2018<\/a>\uff09\u3002TfR \u662f\u540c\u578b\u4e8c\u805a\u4f53 II \u578b\u8de8\u819c\u86cb\u767d\uff0c\u6bcf\u4e2a\u5355\u4f53\u7531\u4e09\u4e2a\u7ec6\u80de\u5916\u7ed3\u6784\u57df\uff08\u4e00\u4e2a\u86cb\u767d\u9176\u6837\u7ed3\u6784\u57df\u3001\u4e00\u4e2a\u8d1f\u8d23\u4e8c\u805a\u5316\u7684\u87ba\u65cb\u7ed3\u6784\u57df\u548c\u4e00\u4e2a\u63a7\u5236\u914d\u4f53\u7ed3\u5408\u7684\u9876\u7aef\u7ed3\u6784\u57df\uff09\u3001\u4e00\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\u548c\u4e00\u4e2a\u77ed\u7ec6\u80de\u8d28\u5c3e\u90e8\u7ec4\u6210\uff08Montemiglio\u7b49\u4eba\uff0c2019<\/a> \u5e74).TfR \u7684\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u7c7b\u4f3c\u4e8e\u8774\u8776\u72b6\u3002TfR \u5b9a\u4f4d\u4e8e\u8d28\u819c\uff0c\u8bb8\u591a\u6709\u5305\u819c\u548c\u65e0\u5305\u819c\u7684\u75c5\u6bd2\uff0c\u5982\u65b0\u4e16\u754c\u51fa\u8840\u70ed\u6c99\u7c92\u75c5\u6bd2\u3001\u4e19\u578b\u809d\u708e\u75c5\u6bd2 \uff08HCV\uff09 \u4ee5\u53ca\u4eba\u548c\u72ac\u7ec6\u5c0f\u75c5\u6bd2\u4f7f\u7528 TfR \u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\uff08Parker \u7b49\u4eba\uff0c2001<\/a> \u5e74;Wessling-Resnick\uff0c2018<\/a> \u5e74\uff09\u3002<\/p>\n\n\n\n

2024 \u5e74\uff0cLiao \u7b49\u4eba\u786e\u5b9a\u4eba\u7c7b TfR \u662f\u4ecb\u5bfc SARS-CoV-2 \u611f\u67d3\u7684\u53d7\u4f53\uff08Liao et al.\uff0c 2024<\/a>\uff09\u3002\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4e32\u8054\u4eb2\u548c\u7eaf\u5316\u8d28\u8c31 \uff08TAP-MS\uff09 \u6765\u9274\u5b9a\u4e0e Spike \u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002TAP-MS \u4f7f\u7528\u4e24\u6b65\u4eb2\u548c\u7eaf\u5316\u65b9\u6cd5\u9274\u5b9a\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u7136\u540e\u8fdb\u884c\u57fa\u4e8e\u8d28\u8c31\u7684\u86cb\u767d\u8d28\u9274\u5b9a\uff08Gingras\u7b49\u4eba\uff0c2007<\/a> \u5e74\uff09\u3002\u4e3a\u4e86\u9274\u5b9a Spike \u76f8\u4e92\u4f5c\u7528\u86cb\u767d\uff0c\u5c06\u4eba\u80ba\u7ec6\u80de \uff08Calu-3\uff09 \u88c2\u89e3\u7269\u4e0e SARS-CoV-2 Spike \u4e00\u8d77\u5b75\u80b2\uff0c\u7136\u540e\u4f9d\u6b21\u7528 S1 \u548c S2 \u6297\u4f53\u5bf9\u86cb\u767d\u8d28\u590d\u5408\u7269\u8fdb\u884c\u514d\u75ab\u6c89\u6dc0\uff0c\u7136\u540e\u4f7f\u7528\u6db2\u76f8\u8272\u8c31\u4e32\u8054\u8d28\u8c31\u6cd5\u8fdb\u884c\u5206\u6790\u3002\u8fd9\u4ea7\u751f\u4e86 293 \u4e2a\u523a\u7a81\u76f8\u4e92\u4f5c\u7528\u4f34\u4fa3\uff0c\u5176\u4e2d 42 \u4e2a\u662f\u8de8\u819c\u86cb\u767d\uff0c9 \u4e2a\u5728\u7ec6\u80de\u819c\u4e0a\u8868\u8fbe\uff0c2 \u4e2a\u4e0e\u75c5\u6bd2\u8fdb\u5165\u6709\u5173\uff1aACE2 \u548c TfR\u3002\u6709\u8da3\u7684\u662f\uff0cTfR \u5728\u5c0f\u9f20\u7684\u6c14\u7ba1\u548c\u80ba\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5e76\u4e14 TfR \u80ba\u8868\u8fbe\u5728\u7334\u5b50\u548c\u4eba\u6e90\u5316 ACE2 \u5c0f\u9f20\u611f\u67d3 SARS-CoV-2 \u540e\u589e\u52a0\u3002ELISA\u3001SPR \u548c Co-IP \u5b9e\u9a8c\u8868\u660e\uff0cSARS-CoV-2 \u523a\u7a81\u86cb\u767d\u76f4\u63a5\u4e0e\u4eba TfR \u7ed3\u5408\uff0c\u4f46\u4e0d\u4e0e\u5c0f\u9f20\u6216\u4ed3\u9f20 TfR \u7ed3\u5408\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u5bf9 SARS-CoV-2 \u8010\u836f\u7684\u5a74\u513f\u4ed3\u9f20\u53d9\u5229\u4e9a\u80be\u7ec6\u80de \uff08BHK-21\uff09 \u548c C57 \u5c0f\u9f20\u4e2d\u8868\u8fbe\u4eba TfR\uff0c\u5bfc\u81f4\u5b83\u4eec\u72ec\u7acb\u4e8e ACE2 \u611f\u67d3\u3002\u7531\u4e8e TfR \u75c5\u6bd2\u590d\u5408\u7269\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u548c\u5185\u4f53\u5185\uff0c\u8fd9\u8868\u660e TfR \u53ef\u80fd\u4f5c\u4e3a\u66ff\u4ee3\u53d7\u4f53\uff0c\u5728\u975e ACE2 \u6216 TMPRSS2 \u8868\u8fbe\u7684\u7ec6\u80de\u4e2d\u4fc3\u8fdb SARS-CoV-2 \u5185\u541e\u4f5c\u7528\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u89e3\u51b3 TMPRSS2 \u5728 TfR\/SARS-CoV-2 \u8fdb\u5165\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca COVID-19 \u60a3\u8005\u4eba\u4f53\u7ec4\u7ec7\u4e2d TfR \u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/p>\n\n\n\n

3.2. CD147\u7684<\/h3>\n\n\n\n

\u4eba\u7c7b\u5206\u5316\u7c07 147 \uff08CD147\uff09 \u4e5f\u79f0\u4e3a\u7ec6\u80de\u5916\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u8bf1\u5bfc\u5242 \uff08EMMPRIN\uff09\u3001HAb18G \u548c basigin \u662f\u4e00\u79cd I \u578b\u8de8\u819c\u86cb\u767d\u548c\u514d\u75ab\u7403\u86cb\u767d \uff08Ig\uff09 \u8d85\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u666e\u904d\u8868\u8fbe\u5e76\u5728\u80ce\u513f\u3001\u795e\u7ecf\u5143\u3001\u6dcb\u5df4\u7ec6\u80de\u548c\u764c\u75c7\u53d1\u5c55\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff08Gabison et al.\uff0c 2005<\/a>\uff09\u3002CD147 \u5305\u62ec\u4e24\u4e2a Ig \u6837\u7ed3\u6784\u57df\u3001\u4e00\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\u548c\u4e00\u4e2a\u77ed\u7ec6\u80de\u8d28\u5c3e\u90e8 \uff08Gabison et al.\uff0c 2005<\/a>\uff09\u3002CD147 \u5b58\u5728\u56db\u79cd\u4e9a\u578b\uff0c\u5c3d\u7ba1\u4e9a\u578b 2 \u662f\u6700\u5e7f\u6cdb\u8868\u8fbe\u548c\u7814\u7a76\u6700\u5145\u5206\u7684 \uff08Gabison et al.\uff0c 2005<\/a>\uff09\u3002\u591a\u79cd\u75c5\u539f\u4f53\u4f7f\u7528 CD147 \u6765\u589e\u5f3a\u611f\u67d3\u3002CD147 \u662f\u4eba\u7c7b\u759f\u75be\u5bc4\u751f\u866b\u6076\u6027\u759f\u539f\u866b<\/em>\u8fdb\u5165\u7ea2\u7ec6\u80de\uff08\u7ea2\u7ec6\u80de\uff09\u7684\u5fc5\u9700\u53d7\u4f53\uff08Crosnier\u7b49\u4eba\uff0c2011<\/a> \u5e74;Zhang et al.\uff0c 2018<\/a>\uff09\u3002\u81f4\u75c5\u83cc\u8111\u819c\u708e\u5948\u745f\u83cc<\/em>\u4f7f\u7528 CD147 \u8fdb\u5165\u4eba\u5185\u76ae\u7ec6\u80de\uff0c\u5bfc\u81f4\u8111\u5185\u8840\u7ba1\u5b9a\u690d\uff08Bernard et al.\uff0c 2014<\/a>\uff09\u3002\u4e0e HIV-1 \u8863\u58f3\u7ed3\u5408\u7684\u5bbf\u4e3b\u86cb\u767d\u4eb2\u73af\u86cb\u767d A \uff08CypA\uff09 \u53ef\u4ee5\u4e0e CD147 \u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u589e\u5f3a HIV-1 \u611f\u67d3\uff08Pushkarsky et al.\uff0c 2001<\/a>\uff09\u3002\u6b64\u5916\uff0cSARS-CoV \u6838\u8863\u58f3 \uff08N\uff09 \u4e5f\u4e0e CypA \u7ed3\u5408\uff0cCD147 \u6291\u5236\u80bd\u7684\u8868\u8fbe\u51cf\u5c11\u4e86 SARS-CoV \u611f\u67d3\uff08Chen\u7b49\u4eba\uff0c2005<\/a> \u5e74\uff09\u3002CD147 \u4f5c\u4e3a SARS-CoV-2 \u611f\u67d3\u7684\u66ff\u4ee3\u53d7\u4f53\u7684\u4f5c\u7528\u662f\u51b3\u5b9a\u6027\u7684\u3002Wang \u7b49\u4eba\u7684\u521d\u6b65\u62a5\u544a\u4f7f\u7528 SPR\u3001ELISA \u548c Co-IP \u6d4b\u5b9a\u68c0\u6d4b\u5230 SARS-CoV-2 \u523a\u7a81 RBD \u548c CD147 \u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff08Wang\u7b49\u4eba\uff0c2020<\/a> \u5e74\uff09\u3002\u7535\u5b50\u663e\u5fae\u955c\u5728\u75c5\u6bd2\u611f\u67d3\u7684 Vero E6 \u7ec6\u80de\u4ee5\u53ca\u4ece COVID-19 \u60a3\u8005\u5206\u79bb\u7684\u80ba\u548c\u80be\u7ec4\u7ec7\u4e2d\u68c0\u6d4b\u5230 CD147 \u548c Spike \u4e4b\u95f4\u7684\u5171\u5b9a\u4f4d\u3002\u901a\u8fc7 shRNA \u6c89\u9ed8 CD147 \u51cf\u5c11\u4e86 Vero E6 \u548c BEAS-2B \u7ec6\u80de\u7cfb\u4e2d\u7684 SARS-CoV-2 \u611f\u67d3\u3002\u76f8\u53cd\uff0c\u5728\u4e0d\u654f\u611f\u7ec6\u80de\u7cfb BHK-21 \u4e2d\u8fc7\u8868\u8fbe CD147 \u4f1a\u589e\u5f3a\u611f\u67d3\u3002\u6b64\u5916\uff0c\u5728\u4eba CD147 \uff08hCD147\uff09 \u7684\u80ba\u90e8\u68c0\u6d4b\u5230 SARS-CoV-2\uff0c\u4f46\u5728\u91ce\u751f\u578b \uff08WT\uff09 \u5c0f\u9f20\u7684\u80ba\u4e2d\u672a\u68c0\u6d4b\u5230\u3002\u5c3d\u7ba1\u5728 COVID-19 \u60a3\u8005\u80ba\u7ec4\u7ec7\u7684\u6dcb\u5df4\u7ec6\u80de\u4e2d\u68c0\u6d4b\u5230\u75c5\u6bd2\u9897\u7c92\uff0c\u4f46\u672a\u53d1\u73b0 CD147 \u548c ACE2 \u4e4b\u95f4\u5b58\u5728\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\u6216\u5171\u5b9a\u4f4d\u3002\u5728\u6d3b\u5316\u7684 CD4 \u548c CD8 T \u7ec6\u80de\u4e2d\uff0cCD147 \u7684\u8868\u8fbe\u589e\u52a0\uff0c\u4f46 ACE2 \u7684\u8868\u8fbe\u589e\u52a0\u3002\u8fd9\u5bfc\u81f4 SARS-CoV-2 \u5047\u75c5\u6bd2\u611f\u67d3\u589e\u52a0\u3002\u6700\u540e\uff0c\u5bf9 COVID-19 \u60a3\u8005\u7684\u6613\u611f\u7ec6\u80de\u7cfb \uff08BHK-21-CD147\uff09 \u548c\u80ba\u7ec4\u7ec7\u7684\u7535\u5b50\u663e\u5fae\u955c\u663e\u793a\uff0cSARS-CoV-2 \u53ef\u80fd\u901a\u8fc7 CD147 \u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e CD147 \u4f5c\u4e3a\u66ff\u4ee3\u53d7\u4f53\uff0c\u7279\u522b\u662f\u5728\u4f4e ACE2 \u8868\u8fbe\u7ec6\u80de\uff08\u5982\u80ba\u548c\u6c14\u7ba1\uff09\u4e2d\u3002<\/p>\n\n\n\n

+<\/sup>+<\/sup><\/p>\n\n\n\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4e24\u9879\u72ec\u7acb\u7684\u968f\u8bbf\u7814\u7a76\u53d1\u73b0 CD147 \u548c SARS-CoV-2 Spike \u4e4b\u95f4\u6ca1\u6709\u76f8\u4e92\u4f5c\u7528\uff08Ragotte\u7b49\u4eba\uff0c2021<\/a> \u5e74;Shilts\u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09\u3002Shilts \u53ca\u5176\u540c\u4e8b\u751f\u4ea7\u4e86\u91cd\u7ec4 SARS-CoV-2 \u523a\u7a81\u86cb\u767d\u548c CD147 \u86cb\u767d\uff0c\u5e76\u4f7f\u7528\u751f\u5316\u5206\u6790\u6765\u6d4b\u8bd5\u5b83\u4eec\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53d1\u73b0\u5b83\u4eec\u4e4b\u95f4\u51e0\u4e4e\u6ca1\u6709\u7ed3\u5408\u3002\u6b64\u5916\uff0c\u6572\u4f4e\u4eba\u80ba\u4e0a\u76ae\u7ec6\u80de\u7cfb \uff08Calu-3\uff09 \u4e2d\u7684 ACE2 \u6d88\u9664\u4e86\u4ed6\u4eec\u5bf9 SARS-CoV-2 \u611f\u67d3\u7684\u6613\u611f\u6027\uff0c\u800c\u6572\u4f4e CD147 \u6216 MHC-I \u86cb\u767d \u03b2-2-\u5fae\u7403\u86cb\u767d \uff08B2M\uff09 \u5219\u6ca1\u6709\uff08Shilts\u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09\u3002\u540c\u6837\uff0cRagotte \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cRBD \u6216\u5168\u957f\u523a\u7a81\u5747\u672a\u4e0e\u7ec6\u83cc\u6216\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u7684 CD147\uff08\u4e9a\u578b 2\uff09\u7ed3\u5408\uff0c\u800c CD147 \u4e0e\u6765\u81ea\u6076\u6027\u759f\u539f\u866b<\/em>\u7684\u7f51\u7ec7\u7ea2\u7ec6\u80de\u7ed3\u5408\u86cb\u767d\u540c\u6e90\u7269 5 \uff08RH5\uff09 \u4e4b\u95f4\u5b58\u5728\u5f3a\u70c8\u7684\u76f8\u4e92\u4f5c\u7528\uff08Ragotte\u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09\u3002\u9274\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a CD147 \u5728 SARS-CoV-2 \u611f\u67d3\u4e2d\u7684\u786e\u5207\u4f5c\u7528\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u5bfb\u6c42\u786e\u5b9a CD147 \u4e9a\u578b\u548c\/\u6216\u591a\u79cd\u523a\u7a81\u86cb\u767d\u4e4b\u95f4\u662f\u5426\u53d1\u751f\u5dee\u5f02\u7ed3\u5408\u3002<\/p>\n\n\n\n

3.3. ASGR1 & KREMEN1<\/h3>\n\n\n\n

\u553e\u6db2\u9178\u7cd6\u86cb\u767d\u53d7\u4f53 1 \uff08ASGR1\uff09 \u662f\u4e00\u79cd\u5185\u541e\u5faa\u73af\u53d7\u4f53\uff0c\u53ef\u7ed3\u5408\u8840\u6db2\u4e2d\u79ef\u6db2\u9178\u7cd6\u86cb\u767d\u5e76\u4fc3\u8fdb\u5b83\u4eec\u5728\u809d\u810f\u5185\u7684\u5185\u541e\u4f5c\u7528\u548c\u6eb6\u9176\u4f53\u964d\u89e3 \uff08Ashwell \u548c Harford\uff0c 1982<\/a>\uff09\u3002\u4e0e DC\/L-SIGN \u4e00\u6837\uff0cASGR1 \u662f\u4e00\u79cd CLR\uff0c\u5b83\u4f7f\u7528\u5176\u7ec6\u80de\u5916\u78b3\u6c34\u5316\u5408\u7269\u8bc6\u522b\u7ed3\u6784\u57df \uff08CRD\uff09 \u6765\u8bc6\u522b\u914d\u4f53\uff0c\u4e3b\u8981\u5728\u809d\u7ec6\u80de\uff08\u809d\u7ec6\u80de\uff09\u8868\u9762\u8868\u8fbe\uff08Hoober\uff0c2020<\/a>\uff09\u3002\u4e19\u578b\u809d\u708e\u75c5\u6bd2 \uff08HCV\uff09 \u88ab\u8ba4\u4e3a\u4f7f\u7528 ASGR1 \u8fdb\u5165\u809d\u7ec6\u80de\uff08Cocquerel \u7b49\u4eba\uff0c2006<\/a> \u5e74;Saunier et al.\uff0c 2003<\/a>\uff09\u3002\u542b\u6709\u8de8\u819c\u86cb\u767d 1 \uff08KREMEN1\uff09 \u7684 Kringle \u662f\u4e00\u79cd\u53c2\u4e0e\u8c03\u8282 Wnt\/\u03b2-catenin \u4fe1\u53f7\u8f6c\u5bfc\u7684 I \u578b\u8de8\u819c\u53d7\u4f53 \uff08\u6bdb et al.\uff0c 2002<\/a>\uff09\u3002\u8be5\u86cb\u767d\u8d28\u5177\u6709\u7ec6\u80de\u5916 Kringle\u3001WSC \u548c CUB \u7ed3\u6784\u57df\uff0c\u8fd9\u4e9b\u7ed3\u6784\u57df\u5bf9\u4e8e\u914d\u4f53\u548c\u5171\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u81f3\u5173\u91cd\u8981\uff08Zebisch\u7b49\u4eba\uff0c2016<\/a> \u5e74\uff09\u3002KREMEN1\u666e\u904d\u8868\u8fbe\uff0c\u5728\u76ae\u80a4\u548c\u98df\u7ba1\u4e2d\u8868\u8fbe\u7279\u522b\u9ad8\uff0c\u5e76\u4f5c\u4e3a\u8bb8\u591a\u80a0\u9053\u75c5\u6bd2\u7684\u8fdb\u5165\u53d7\u4f53\uff08Staring\u7b49\u4eba\uff0c2018<\/a> \u5e74\uff09\u3002<\/p>\n\n\n\n

2022 \u5e74\uff0cGu \u53ca\u5176\u540c\u4e8b\u786e\u5b9a\u542b\u6709\u8de8\u819c 1 \uff08KREMEN1\uff09 \u7684\u553e\u6db2\u9178\u7cd6\u86cb\u767d\u53d7\u4f53 1 \uff08ASGR1\uff09 \u548c\u542b\u6709 Kringle \u7684\u66ff\u4ee3\u53d7\u4f53\u662f SARS-CoV-2 \u8fdb\u5165\u7684\u66ff\u4ee3\u53d7\u4f53\uff08Gu et al.\uff0c 2022<\/a>\uff09\u3002\u4e3a\u4e86\u9274\u5b9a ACE2 \u4ee5\u5916\u7684 SARS-CoV-2 \u53d7\u4f53\uff0c\u5728 HEK293 \u7ec6\u80de\u4e2d\u5355\u72ec\u8868\u8fbe\u7f16\u7801 5054 \u4e2a\u4eba\u819c\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u7684\u8d28\u7c92\uff0c\u5e76\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u6d4b\u91cf\u5b83\u4eec\u4e0e SARS-CoV-2 \u523a\u7a81\u7ec6\u80de\u5916\u7ed3\u6784\u57df \uff08S-ECD\uff09 \u7684\u7ed3\u5408\u3002\u8be5\u7b5b\u9009\u786e\u5b9a\u4e86 12 \u79cd\u7ed3\u5408 Spike \u7684\u819c\u86cb\u767d\uff0c\u5305\u62ec ASGR1 \u548c KREMEN1 \uff08Gu et al.\uff0c 2022<\/a>\uff09\u3002\u6709\u8da3\u7684\u662f\uff0cKREMEN1 \u548c ASGR1 \u7684\u8868\u8fbe\u8db3\u4ee5\u4f7f Spike \u5047\u578b SARS-CoV-2 \u8fdb\u5165 ACE2-KO HEK293T\u7ec6\u80de\uff0c\u4f46\u4e0d\u80fd\u8fdb\u5165 SARS-CoV \u6216 MERS-CoV\u3002ASGR1 \u548c KREMEN1 \u90fd\u5141\u8bb8 Spike \u5047\u578b SARS-CoV-2 \u9897\u7c92\u9644\u7740\u5728\u7ec6\u80de\u8868\u9762\uff0c\u5e76\u4e14\u4e24\u79cd\u86cb\u767d\u8d28\u90fd\u4e0e Spike \u5171\u5b9a\u4f4d\u3002\u8fd9\u4e9b\u7ed3\u679c\u5df2\u901a\u8fc7\u771f\u5b9e\u7684 SARS-CoV-2 \u5f97\u5230\u8bc1\u5b9e\u3002\u4e3a\u4e86\u786e\u5b9a ASG1 \u548c KREMEN1 \u5728\u4f53\u5185<\/em>\u7684\u4f5c\u7528\uff0c\u7f16\u7801\u4eba ASGR1\u3001KREMEN1 \u6216 ACE2 \u7684\u6162\u75c5\u6bd2\u9897\u7c92\u5728\u5c0f\u9f20\u9f3b\u5185\u8868\u8fbe\uff0c\u7136\u540e\u7528 SARS-CoV-2 \u523a\u7a81\u5047\u75c5\u6bd2\u6216\u6b63\u5b97 SARS-CoV-2 \u653b\u51fb\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u80ba\u5185\u8868\u8fbe ACE2 \u3001 ASGR1 \u548c KREMEN1 \u7684\u5c0f\u9f20\u7684\u75c5\u6bd2\u6ef4\u5ea6\u663e\u8457\u5347\u9ad8\u3002\u6709\u8da3\u7684\u662f\uff0c\u867d\u7136 ACE2 \u4ec5\u4e0e\u523a\u7a81 RBD \u7ed3\u5408\uff0c\u4f46 KREMEN1\u901a\u8fc7\u5176 CUB \u7ed3\u6784\u57df\u4e0e\u523a\u7a81 RBD \u548c NTD \u7ed3\u5408\uff0c\u800c ASGR1 \u901a\u8fc7\u5176 CTD \u7ed3\u6784\u57df\u7ed3\u5408\u523a\u7a81\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u5185\u7684\u6240\u6709\u4e09\u4e2a\u533a\u57df\uff08RBD\u3001NTD \u548c S2\uff09\u3002\u56e0\u4e3a\u5b58\u5728\u9488\u5bf9 Spike NTD \u7684\u4e2d\u548c\u6297\u4f53\uff08Brouwer\u7b49\u4eba\uff0c2020<\/a> \u5e74;Chi et al.\uff0c 2020<\/a>;Liu et al.\uff0c 2020<\/a>\uff09\uff0c\u8fd9\u8868\u660e KREMEN1 \u548c ASGR1 \u4e0e AXL \u4e00\u6837\uff0c\u53ef\u80fd\u5bf9\u5efa\u7acb SARS-CoV-2 \u611f\u67d3\u5f88\u91cd\u8981\u3002\u63a5\u4e0b\u6765\uff0cGu \u7b49\u4eba\u7b5b\u9009\u4e86 39 \u79cd\u80ba\u764c\u548c\u809d\u764c\u7ec6\u80de\u7cfb\uff0c\u786e\u5b9a\u4e86 13 \u79cd\u6613\u53d7 SARS-CoV-2 \u611f\u67d3\u7684\u5f71\u54cd\u3002\u5728 ACE2 \u4e2d\u548c\u6297\u4f53\u5b58\u5728\u4e0b\u5171\u5b75\u80b2 SARS-CoV-2 \u5047\u75c5\u6bd2\u53ef\u6291\u5236\u5927\u591a\u6570\u7ec6\u80de\u7cfb\u7684\u75c5\u6bd2\u611f\u67d3\uff0c\u80ba \uff08HTB182\uff09 \u548c\u809d\u810f \uff08Li7\uff09 \u7ec6\u80de\u7cfb\u9664\u5916\u3002\u76f8\u53cd\uff0c\u6572\u4f4e HTB-182 \u7ec6\u80de\u4e2d\u7684 KREMEN1 \u6216 Li7 \u7ec6\u80de\u4e2d\u7684 ASGR1 \u53ef\u663e\u8457\u964d\u4f4e\u5176\u5bf9\u6b63\u5b97 SARS-CoV-2 \u7684\u611f\u67d3\u3002\u5206\u6790\u5355\u7ec6\u80de RNA \u6d4b\u5e8f\u6570\u636e\u786e\u5b9a ACE2\u3001ASGR1 \u548c KREMEN1\uff0c\u7edf\u79f0\u4e3a ASK \u53d7\u4f53\uff0c\u5728 COVID-19 \u60a3\u8005\u4e0a\u547c\u5438\u9053\u7684\u4e0a\u76ae\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u4e2d\u5747\u663e\u8457\u8868\u8fbe\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e KREMEN1 \u548c ASGR1 \u4ee3\u8868\u72ec\u7acb\u4e8e ACE2 \u7684 SARS-CoV-2 \u8fdb\u5165\u7684\u66ff\u4ee3\u53d7\u4f53\u3002<\/p>\n\n\n\n

3.4. \u65a7\u5934<\/h3>\n\n\n\n

AXL\/UFO \u662f\u4e00\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176 \uff08RTK\uff09\uff0c\u6700\u521d\u5728\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u4e2d\u88ab\u53d1\u73b0 \uff08Liu et al.\uff0c 1988<\/a>\uff09\u3002\u8be5\u86cb\u767d\u8d28\u5305\u542b\u7ec6\u80de\u5916\u3001\u8de8\u819c\u548c\u7ec6\u80de\u5185\u7ed3\u6784\u57df\uff0c\u5176\u4e2d\u7ec6\u80de\u5916\u533a\u57df\u7531\u4e24\u4e2a\u514d\u75ab\u7403\u86cb\u767d \uff08Ig\uff09 \u6837\u91cd\u590d\u5e8f\u5217\u548c\u4e24\u4e2a\u7ea4\u8fde\u86cb\u767d III \u578b \uff08Fro II\uff09 \u6837\u91cd\u590d\u5e8f\u5217\u7ec4\u6210\uff0c\u5b83\u4eec\u53c2\u4e0e\u7ed3\u5408\u914d\u4f53 Gas6 \uff08Linger et al.\uff0c 2008<\/a>\uff09\u3002\u6fc0\u9176\u6d3b\u6027\u6e90\u4e8e AXL \u7684\u7ec6\u80de\u5185\u7ed3\u6784\u57df\u3002\u4e0e Tyro3 \u548c Mer \u4e00\u8d77\uff0cAxl \u662f RTK \u7684 TAM \u5bb6\u65cf\u7684\u4e00\u90e8\u5206\uff0c\u8be5\u5bb6\u65cf\u5728\u5305\u62ec\u8840\u6db2\u3001\u5927\u8111\u3001\u5fc3\u810f\u548c\u809d\u810f\u5728\u5185\u7684\u591a\u79cd\u7ec4\u7ec7\u4e2d\u5e7f\u6cdb\u8868\u8fbe\uff08Linger et al.\uff0c 2008<\/a>\uff09\u3002TAM \u53d7\u4f53\u8c03\u8282\u7ec6\u80de\u5b58\u6d3b\u5e76\u5728\u514d\u75ab\u7cfb\u7edf\u53d1\u80b2\u4e2d\u53d1\u6325\u591a\u79cd\u4f5c\u7528 \uff08Linger et al.\uff0c 2008<\/a>\uff09\u3002AXL \u662f\u9ec4\u75c5\u6bd2\u7684\u5bbf\u4e3b\u8fdb\u5165\u56e0\u5b50\uff0c\u5305\u62ec\u767b\u9769\u70ed\u75c5\u6bd2 \uff08Meertens et al.\uff0c 2012<\/a>\uff09 \u548c\u5be8\u5361\u75c5\u6bd2 \uff08Meertens et al.\uff0c 2017<\/a>\uff09\u3002<\/p>\n\n\n\n

Wang \u53ca\u5176\u540c\u4e8b\u4f7f\u7528 TAP-MS \u786e\u5b9a\u4e86\u4eba\u80ba \uff08H1299\uff09 \u548c\u652f\u6c14\u7ba1 \uff08BEAS-2B\uff09 \u4e0a\u76ae\u7ec6\u80de \uff08S. Wang\u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09 \u4e2d SARS-CoV-2 \u523a\u7a81\u548c AXL \u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u8fd9\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u5728 H1299 \u548c BEAS-2B \u7ec6\u80de\u4e2d\u7a33\u5b9a\u8868\u8fbe\u5e26\u6709\u4eb2\u548c\u7eaf\u5316\u6807\u7b7e \uff08S\/SBP\uff09 \u7684\u523a\u7a81\u6216\u5bf9\u7167\u6d41\u611f H5N6 \u8840\u51dd\u7d20 \uff08HA\uff09\uff0c\u79f0\u4e3a\u8bf1\u9975\u86cb\u767d\u3002\u4f7f\u7528 Strep \uff08SBP\uff09 \u548c S \u73e0\u8fdb\u884c\u4e32\u8054\u4eb2\u548c\u7eaf\u5316\u540e\uff0c\u4f7f\u7528\u6db2\u76f8\u8272\u8c31\u8d28\u8c31 \uff08LC MS\/MS\uff09 \u9274\u5b9a\u4e0e Spike \u6216 HA \uff08\u730e\u7269\uff09 \u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002\u7edf\u8ba1\u5efa\u6a21\u548c\u8ba1\u7b97\u7b5b\u9009\u786e\u5b9a AXL\u3001\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 \uff08EGFR\uff09 \u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53 \uff08LDLR\uff09 \u662f Spike \u7684\u4e3b\u8981\u53d7\u4f53\uff0c\u5c3d\u7ba1\u53ea\u6709 AXL \u4e0e\u7ec6\u80de\u819c\u7684 Spike \u5171\u5b9a\u4f4d\u3002\u6709\u8da3\u7684\u662f\uff0cAXL \u4e0e Spike \u7684 N \u7aef\u7ed3\u6784\u57df \uff08NTD\uff09 \u7ed3\u5408\uff0c\u800c\u4e0d\u662f RBD\u3002\u8fd9\u5f88\u6709\u8da3\uff0c\u56e0\u4e3a\u4ece COVID-19 \u60a3\u8005\u4e2d\u5206\u79bb\u7684\u4e00\u4e9b\u5355\u514b\u9686\u6297\u4f53\u4e0e Spike RBD \u4ee5\u5916\u7684\u4f4d\u70b9\u7ed3\u5408\uff08Brouwer\u7b49\u4eba\uff0c2020<\/a> \u5e74;Chi et al.\uff0c 2020<\/a>;Liu et al.\uff0c 2020<\/a>\uff09\u3002\u5728\u4e0d\u654f\u611f\u7684 HEK293T \u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe AXL \u6216 ACE2 \u4fc3\u8fdb\u4e86 SARS-CoV-2 \u5047\u75c5\u6bd2\u548c\u771f\u6b63\u7684 SARS-CoV-2 \u611f\u67d3\u3002\u76f8\u53cd\uff0c\u6572\u9664 H1299 \u7ec6\u80de\u548c\u539f\u4ee3\u4eba\u80ba\u7c7b\u5668\u5b98\u4e2d\u7684 AXL \u51cf\u5c11\u4e86\uff0c\u4f46\u5e76\u672a\u5b8c\u5168\u6d88\u9664 SARS-CoV-2 \u611f\u67d3\u3002AXL \u9633\u6027\u7ec6\u80de\u4e0e COVID-19 \u60a3\u8005\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2 \uff08BALF\uff09 \u4e2d\u7684 SARS-CoV-2 \u9633\u6027\u7ec6\u80de\u7684\u76f8\u5173\u6027\u9ad8\u4e8e ACE2 \u9633\u6027\u7ec6\u80de\u3002\u7531\u4e8e ACE2 \u5728\u4eba\u80ba\u548c\u6c14\u7ba1\u4e2d\u7684\u8868\u8fbe\u8f83\u4f4e\uff08S. Wang et al.\uff0c 2021<\/a>\uff09\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e AXL \u53ef\u4ee5\u4f5c\u4e3a SARS-CoV-2 \u8fdb\u5165\u4eba\u80ba\u4e0a\u76ae\u7ec6\u80de\u7684\u66ff\u4ee3\u53d7\u4f53\uff0c\u72ec\u7acb\u4e8e ACE2\u3002<\/p>\n\n\n\n

3.5. TMEM106B<\/h3>\n\n\n\n

TMEM106B \u662f\u4e00\u79cd II \u578b\u665a\u671f\u5185\u4f53\/\u6eb6\u9176\u4f53\u8de8\u819c\u86cb\u767d\uff0c\u4e3b\u8981\u5728\u5927\u8111\u3001\u5fc3\u810f\u3001\u7532\u72b6\u817a\u3001\u80be\u4e0a\u817a\u548c\u777e\u4e38\u4e2d\u8868\u8fbe\uff08Lang\u7b49\u4eba\uff0c2012<\/a> \u5e74;Uhl\u00e9n\u7b49\u4eba\uff0c2015<\/a> \u5e74\uff09\u3002\u8be5\u86cb\u767d\u8d28\u5305\u542b\u4e00\u4e2a N \u672b\u7aef\u80de\u8d28\u7ed3\u6784\u57df\u3001\u4e00\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\u548c\u4e00\u4e2a\u7cd6\u57fa\u5316 C \u672b\u7aef\u7ba1\u8154\u7ed3\u6784\u57df \uff08LD\uff09\uff0c\u8be5\u7ed3\u6784\u57df\u53ef\u4ee5\u5728\u4e0e\u6eb6\u9176\u4f53\u86cb\u767d\u9176\u7ed3\u5408\u65f6\u89e3\u79bb\uff08Feng\u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09\u3002TMEM106B \u53ef\u4ee5\u4e0e\u5176\u540c\u6e90\u7269TMEM106C\u7ed3\u5408\u5f62\u6210\u540c\u6e90\u4e8c\u805a\u4f53\u548c\u5f02\u4e8c\u805a\u4f53\uff08Stagi\u7b49\u4eba\uff0c2014<\/a> \u5e74\uff09\u3002\u51e0\u79cd\u6eb6\u9176\u4f53\u86cb\u767d\u53ef\u4ee5\u7ed3\u5408TMEM106B\uff0c\u5305\u62ec\u86cb\u767d\u9176\u7ec4\u7ec7\u86cb\u767d\u9176 D\uff08Feng\u7b49\u4eba\uff0c2020<\/a> \u5e74\uff09\uff0cTMEM106B\u53c2\u4e0e\u591a\u79cd\u6eb6\u9176\u4f53\u529f\u80fd\uff0c\u5305\u62ec\u7ef4\u6301\u6eb6\u9176\u4f53 pH \u503c\u548c\u8c03\u8282\u6eb6\u9176\u4f53\u8fd0\u52a8\u548c\u80de\u5410\u4f5c\u7528\u3002TMEM106B\u6c34\u5e73\u7684\u6539\u53d8\u4e0e\u591a\u79cd\u795e\u7ecf\u8ba4\u77e5\u969c\u788d\u6709\u5173\uff0c\u4f8b\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7 \uff08ALS\uff09\u3001\u989d\u989e\u53f6\u53d8\u6027 \uff08FTLD\uff09 \u548c\u5e15\u91d1\u68ee\u75c5\uff08Feng et al.\uff0c 2021<\/a>\uff09\u3002<\/p>\n\n\n\n

\u4e24\u9879\u72ec\u7acb\u7814\u7a76\u5728\u4eba\u809d\u7ec6\u80de\u7cfb \uff08Huh7\uff09 \u4e2d\u4f7f\u7528\u5168\u57fa\u56e0\u7ec4 CRISPR \u6572\u9664\u7b5b\u9009\uff0c\u4ee5\u786e\u5b9a TMEM106B \u662f SARS-CoV-2 \u611f\u67d3\u6240\u9700\u7684\u5bbf\u4e3b\u56e0\u5b50\uff08Baggen\u7b49\u4eba\uff0c2021 \u5e74;<\/a>R. Wang \u7b49\u4eba\uff0c2021<\/a> \u5e74\uff09\u3002\u5728\u51e0\u79cd\u809d\u810f\u548c\u80ba\u7ec6\u80de\u7cfb\u4e2d\u7684\u9a8c\u8bc1\u8bc1\u5b9e\uff0c\u6572\u9664 TMEM106B \u51cf\u5c11\u4e86 SARS-CoV-2 \u611f\u67d3\uff0c\u800c\u91cd\u65b0\u6dfb\u52a0TMEM106B\u633d\u6551\u4e86\u611f\u67d3\u3002\u8fd9\u79cd\u6548\u679c\u5bf9 SARS-CoV-2 \u662f\u7279\u5f02\u6027\u7684\uff0c\u56e0\u4e3aTMEM106B\u5bf9\u4e8e\u611f\u67d3\u4eba\u7c7b\u51a0\u72b6\u75c5\u6bd2 HCoV-229E \u6216 HCoV-OC43 \u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u4e00\u9879\u540e\u7eed\u7814\u7a76\u786e\u5b9a\uff0cTMEM106B \u7684\u7ba1\u8154\u7ed3\u6784\u57df \uff08LD\uff09 \u4e0e SARS-CoV-2 Spike \u7684 RBD \u7ed3\u5408\uff0c\u5e76\u4e14 Spike \u66ff\u6362 \uff08E484D\uff09 \u589e\u52a0\u4e86\u4e24\u8005\u4e4b\u95f4\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u611f\u67d3\uff08Baggen et al.\uff0c 2023<\/a>\uff09\u3002\u4e0d\u540c\u7684 SARS-CoV-2 \u53d8\u4f53\u5229\u7528TMEM106B\u8fdb\u884c\u611f\u67d3\uff0c\u6572\u9664\u786b\u9178\u4e59\u9170\u809d\u7d20\u5408\u6210 \uff08EXT1\uff09 \u6240\u9700\u7684\u57fa\u56e0\u6291\u5236\u4e86 ACE2 \u4f9d\u8d56\u6027\u548c TMEM106B \u4f9d\u8d56\u6027 SARS-CoV-2 \u611f\u67d3\uff0c\u8868\u660e\u786b\u9178\u4e59\u9170\u809d\u7d20\u6709\u52a9\u4e8e\u4e24\u79cd\u611f\u67d3\u9014\u5f84\uff08Baggen \u7b49\u4eba\uff0c2023<\/a> \u5e74\uff09\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8bc1\u5b9e\u4e86 TMEM106B \u5728 ACE2 \u975e\u4f9d\u8d56\u6027\u4f5c\u7528\u5728\u4f53\u5916<\/em>\u800c\u4e0d\u662f\u4f53\u5185<\/em>\u4fc3\u8fdb SARS-CoV-2 \u611f\u67d3\uff08Yan et al.\uff0c 2024<\/a>\uff09\u3002\u5728\u8fd9\u91cc\uff0c\u5c0f\u9f20\u9002\u5e94\u7684 SARS-CoV-2 \u6bd2\u682a \uff08SARS-CoV-2<\/p>\n\n\n\n

MA1<\/sub>\uff09 \u5bfc\u81f4\u4eba\u8111\u7c7b\u5668\u5b98\u548c\u8868\u8fbe\u4eba ACE2 \u7684\u5c0f\u9f20\u5177\u6709\u66f4\u5927\u7684\u795e\u7ecf\u6bd2\u529b\u3002\u7136\u800c\uff0cSARS-CoV-2<\/p>\n\n\n\n

MA1<\/sub>\u4e0d\u4f1a\u589e\u5f3a\u91ce\u751f\u578b \uff08C57BL\/6J\uff09 \u5c0f\u9f20\u7684\u795e\u7ecf\u6bd2\u529b\uff0c\u4e5f\u4e0d\u5bb9\u6613\u611f\u67d3 ACE2 \u7f3a\u9677\u578b \uff08Ace2<\/p>\n\n\n\n

\u2212\/\u2212<\/sup>\uff09 \u5c0f\u9f20\u7f3a\u4e4f\u6216\u8868\u8fbe\u4eba\u7c7bTMEM106B\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u7ed3\u679c\u4f7f\u4eba\u4eec\u5bf9 TMEM106B \u5728\u4fc3\u8fdb ACE2 \u975e\u4f9d\u8d56\u6027 SARS-CoV-2 \u611f\u67d3\u4e2d\u7684\u786e\u5207\u4f5c\u7528\u4ea7\u751f\u4e86\u6000\u7591\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u901a\u8fc7\u6761\u4ef6\u6027\u7f3a\u5931\u6216\u836f\u7406\u5b66\u6291\u5236\u89e3\u51b3 TMEM106B \u5728\u4f53\u5185<\/em>\u7684\u8d21\u732e\uff0c\u5e76\u4f7f\u7528\u5176\u4ed6\u52a8\u7269\u6a21\u578b\u548c\u4e0d\u540c\u7684 SARS-CoV-2 \u6bd2\u682a\/\u53d8\u4f53\u6982\u62ec Yan \u7b49\u4eba\u7684\u7ed3\u679c\u3002<\/p>\n\n\n\n

4. SARS-CoV-2 \u8fdb\u5165\uff1a\u6291\u5236\u6027\u53d7\u4f53<\/h2>\n\n\n\n

\u6291\u5236\u6027\u53d7\u4f53\u662f\u5176\u8868\u8fbe\u51cf\u5c11 SARS-CoV-2 \u611f\u67d3\u7684\u86cb\u767d\u8d28\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u8d77\u5230\u6297\u75c5\u6bd2\u4f5c\u7528\u3002\u4e0b\u9762\u6211\u4eec\u63cf\u8ff0\u4e86\u4e00\u79cd\u8fd9\u6837\u7684\u86cb\u767d\u8d28 LRRC15 \u53ca\u5176\u5bf9 SARS-CoV-2 \u611f\u67d3\u7684\u5f71\u54cd\uff08\u8868 2<\/a>;\u56fe 2<\/a>C).<\/p>\n","protected":false},"excerpt":{"rendered":"

6. \u7ed3\u8bba\u548c\u89c2\u70b9 SARS-CoV-2 \u4ecd\u7136\u662f\u4e00\u4e2a\u91cd\u5927\u7684\u5168\u7403…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-190","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/posts\/190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/comments?post=190"}],"version-history":[{"count":2,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/posts\/190\/revisions"}],"predecessor-version":[{"id":192,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/posts\/190\/revisions\/192"}],"wp:attachment":[{"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/media?parent=190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/categories?post=190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.12099.icu\/wordpress\/wp-json\/wp\/v2\/tags?post=190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}