\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u5fc3\u810f\u75c7\u72b6\u662f COVID-19 \u540e\u51fa\u9662\u540e\u7684\u5e38\u89c1\u62b1\u6028\u3002Carfi \u7b49\u4eba \uff0818\uff09 \u63cf\u8ff0\u4e86\u591a\u8fbe 21% \u7684\u60a3\u8005\u5728\u51fa\u9662\u540e 60 \u5929\u51fa\u73b0\u80f8\u75db\u3002\u5fc3\u60b8\u4e5f\u88ab\u63cf\u8ff0\u4e3a\u591a\u8fbe 9% \u7684\u60a3\u8005\u5728 60 \u5929\u968f\u8bbf\u4e2d\u7684\u5e38\u89c1\u75c7\u72b6\u3002\u9664\u4e86\u88ab\u63cf\u8ff0\u4e3a SARS-CoV-2 \u611f\u67d3\u957f\u671f\u540e\u679c\u4e00\u90e8\u5206\u7684\u4e3b\u89c2\u5fc3\u810f\u75c7\u72b6\u5916\uff0c\u8fd8\u6709\u4e00\u4e9b\u53ef\u8861\u91cf\u7684\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u3002\u636e\u62a5\u9053\uff0c\u611f\u67d3 SARS-CoV-2 \u540e\u4f53\u4f4d\u6027\u5fc3\u52a8\u8fc7\u901f\u7efc\u5408\u5f81 \uff08POTS\uff09 \u7684\u53d1\u75c5\u7387\u589e\u52a0\uff0c\u76ee\u524d\u6b63\u5728\u8c03\u67e5\u786e\u5207\u7684\u60a3\u75c5\u7387 \uff0827\uff09\u3002COVID-19 \u7684\u4e00\u4e9b\u957f\u671f\u5fc3\u8840\u7ba1\u5f71\u54cd\u662f\u6025\u6027\u611f\u67d3\u7684\u7ed3\u679c\u3002\u5728\u4e00\u9879\u9488\u5bf9\u5e74\u8f7b\u3001\u5065\u5eb7\u3001\u6709\u7ade\u4e89\u529b\u7684\u5927\u5b66\u8fd0\u52a8\u5458\u7684\u5927\u578b\u7814\u7a76\u4e2d\uff0c\u591a\u8fbe 2.3% \u7684\u53c2\u4e0e\u8005\u53d1\u73b0\u4e86\u5fc3\u808c\u708e\uff0c\u5176\u4e2d\u5927\u591a\u6570\u662f\u901a\u8fc7\u5fc3\u810f\u78c1\u5171\u632f\u6210\u50cf\u68c0\u6d4b\u5230\u7684\u4e9a\u4e34\u5e8a\u5fc3\u808c\u708e\u3002\u6b64\u5916\uff0c\u5bf9 100 \u540d COVID-19 \u51fa\u9662\u60a3\u8005\u8fdb\u884c\u7684\u968f\u8bbf\u5e38\u89c4\u5fc3\u810f\u78c1\u5171\u632f\u6210\u50cf\u53d1\u73b0\uff0c60% \u7684\u60a3\u8005\u6301\u7eed\u708e\u75c7\uff0c\u591a\u8fbe 71% \u7684\u60a3\u8005\u9ad8\u654f\u808c\u9499\u86cb\u767d T \u6301\u7eed\u5347\u9ad8 \uff0828\uff09\u3002\u8fd9\u4e00\u53d1\u73b0\u7684\u4e34\u5e8a\u76f8\u5173\u6027\u4e00\u76f4\u5b58\u5728\u4e89\u8bae\uff0c\u56e0\u4e3a\u5c1a\u672a\u62a5\u9053\u5176\u4ed6\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u7c7b\u4f3c\u7814\u7a76\uff0c\u4f46\u5b83\u4f3c\u4e4e\u786e\u5b9e\u8868\u660e SARS-CoV-2 \u611f\u67d3\u5bf9\u5fc3\u810f\u7684\u5f71\u54cd\u53ef\u4ee5\u5ef6\u957f \uff0828\uff09\u3002\u6700\u540e\uff0cCOVID-19 \u7684\u6025\u6027\u671f\u5df2\u88ab\u8bc1\u660e\u4e0e\u8d85\u58f0\u5fc3\u52a8\u56fe\u5f02\u5e38\u53d1\u73b0\u7684\u9ad8\u53d1\u751f\u7387\u6709\u5173 \uff0829\uff09\u3002\u5728\u4e00\u9879\u5bf9 1,216 \u540d COVID-19 \u5165\u9662\u60a3\u8005\u7684\u524d\u77bb\u6027\u7814\u7a76\u4e2d\uff0c55% \u7684\u60a3\u8005\u8d85\u58f0\u5fc3\u52a8\u56fe\u5f02\u5e38\uff0c\u5305\u62ec 46 \u540d\u65e2\u5f80\u65e0\u5fc3\u810f\u75c5\u60a3\u8005\u4e2d 901% \u7684\u5f02\u5e38 \uff0829\uff09\u3002\u867d\u7136\u6ca1\u6709\u53d1\u8868\u957f\u671f\u968f\u8bbf\u4e2d\u8d85\u58f0\u5fc3\u52a8\u56fe\u7ed3\u679c\u7684\u6570\u636e\uff0c\u4f46\u5728\u8fd9\u4e9b\u60a3\u8005\u7684\u957f\u671f\u62a4\u7406\u4e2d\u5fc5\u987b\u8003\u8651\u5728\u6025\u6027\u60c5\u51b5\u4e0b\u89c2\u5bdf\u5230\u7684\u5e76\u53d1\u75c7\u3002<\/p>\n\n\n\n
\u5bf9\u4e8e SARS-CoV-2 \u5fc3\u810f\u635f\u4f24\u7684\u53d1\u75c5\u673a\u5236\uff0c\u6709\u51e0\u79cd\u4e0d\u540c\u7684\u673a\u5236\u88ab\u63d0\u51fa\u3002\u65e9\u671f\u63cf\u8ff0\u6027\u5c38\u68c0\u7814\u7a76\u7684\u6c47\u7f16\u6570\u636e\u89c2\u5bdf\u5230\u5fc3\u810f\u7ec4\u7ec7\u5b66\u5206\u6790\u7684\u5404\u79cd\u53d1\u73b0\uff0c\u5305\u62ec\u95f4\u8d28\u708e\u6d78\u6da6\u3001\u5fc3\u808c\u80a5\u5927\u548c\u574f\u6b7b\uff0c\u4ee5\u53ca SARS-CoV-2 \u7684 RT-PCR \u9633\u6027 \uff0830\uff09\u3002\u5982\u524d\u6240\u8ff0\uff0cSARS-CoV-2 \u5bf9\u4f4d\u4e8e\u8868\u9762\u7ec6\u80de\u4e0a\u7684 ACE2 \u53d7\u4f53\u5177\u6709\u4eb2\u548c\u529b\uff0c\u8fd9\u662f\u75c5\u6bd2\u76f4\u63a5\u8fdb\u5165\u7684\u673a\u5236 \uff0817\uff09\u3002\u5728\u4e00\u9879\u5355\u7ec6\u80de RNA \u6d4b\u5e8f\u7814\u7a76\u4e2d\uff0cACE2 \u8868\u8fbe\u5b58\u5728\u4e8e 7.5% \u7684\u808c\u7ec6\u80de\u4e2d\uff0c\u4f7f\u5176\u6210\u4e3a\u76f4\u63a5\u75c5\u6bd2\u635f\u4f24\u98ce\u9669\u589e\u52a0\u7684\u5668\u5b98 \uff0831\uff09\u3002\u5c38\u68c0\u7814\u7a76\u652f\u6301\u4e86\u8fd9\u4e00\u70b9\uff0c\u5176\u4e2d 61.5% \u7684\u60a3\u8005\u7684\u5fc3\u808c\u4e2d\u5b58\u5728 SARS-CoV-2 \u75c5\u6bd2 RNA [32]\u3002\u5728\u75c5\u6bd2\u8f7d\u91cf\u6700\u9ad8 \uff08>1,000 \u62f7\u8d1d\uff09 \u7684\u60a3\u8005\u4e2d\uff0c\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe\u4e5f\u589e\u52a0 \uff0832\uff09\u3002\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\u7684\u589e\u52a0\u4e5f\u88ab\u63d0\u51fa\u4e3a\u5bfc\u81f4\u5185\u76ae\u529f\u80fd\u969c\u788d\u3001\u6591\u5757\u4e0d\u7a33\u5b9a\u3001\u5fc3\u808c\u6897\u6b7b\u548c\u5fc3\u808c\u635f\u4f24\u7684\u5fc3\u810f\u635f\u4f24\u673a\u5236 \uff0833\uff09\u3002\u7531\u4e8e\u5b83\u4e0e\u5fc3\u808c\u708e\u7684\u75c5\u56e0\u7279\u522b\u76f8\u5173\uff0c\u56e0\u6b64\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u75c5\u6bd2\u6297\u539f\u5448\u4f1a\u5bfc\u81f4 CD8+ T \u6dcb\u5df4\u7ec6\u80de\u7684\u7ec6\u80de\u4ecb\u5bfc\u6bd2\u6027\uff0c\u5e76\u4f34\u6709\u76f8\u5173\u7684\u5fc3\u808c\u708e\u75c7 \uff0834\uff09\u3002COVID-19 \u7684\u957f\u671f\u548c\u77ed\u671f\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7\u90fd\u901a\u8fc7\u8fd9\u4e9b\u4e0d\u540c\u7684\u673a\u5236\u8868\u73b0\u51fa\u6765\u3002<\/p>\n\n\n\n
\u4efb\u4f55\u5df2\u77e5\u6709\u6025\u6027\u611f\u67d3\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u5728\u6025\u6027\u611f\u67d3\u540e\u6570\u5468\u81f3\u6570\u6708\u7684\u665a\u671f\u7ee7\u7eed\u51fa\u73b0\u5fc3\u8840\u7ba1\u4e0d\u9002\u7684\u60a3\u8005\uff0c\u90fd\u5e94\u8f6c\u8bca\u7531\u5fc3\u810f\u75c5\u5b66\u4e9a\u4e13\u79d1\u533b\u751f\u8fdb\u884c\u8bc4\u4f30 \uff0835\uff09\u3002\u60a3\u8005\u7684\u8bc4\u4f30\u5e94\u5305\u62ec\u75c5\u53f2\u548c\u4f53\u683c\u68c0\u67e5\u4ee5\u53ca 12 \u5bfc\u8054\u5fc3\u7535\u56fe\u7684\u5168\u9762\u8bc4\u4f30\uff0c\u5e76\u6839\u636e\u6bcf\u79cd\u4e34\u5e8a\u60c5\u51b5\u8003\u8651\u5fc3\u810f\u751f\u7269\u6807\u5fd7\u7269\u548c\u5fc3\u8840\u7ba1\u5f71\u50cf\u5b66 \uff0835\uff09\u3002\u968f\u7740 COVID-19 \u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7\u7684\u7ecf\u9a8c\u4e0d\u65ad\u589e\u957f\uff0c\u6709\u4eba\u63d0\u8bae\u501f\u9274\u6211\u4eec\u5728\u975e COVID-19 \u75be\u75c5\u65b9\u9762\u7684\u7ecf\u9a8c\u6765\u6307\u5bfc\u6211\u4eec\u7684\u5b9e\u8df5 \uff0836\uff09\u3002\u5bf9\u4e8e\u4efb\u4f55\u8bca\u65ad\u4e3a\u5fc3\u808c\u708e\u7684\u60a3\u8005\uff0c\u5e94\u5728\u8bca\u65ad\u540e\u81f3\u5c11 3-6 \u4e2a\u6708\u8fdb\u884c\u9759\u606f\u8d85\u58f0\u5fc3\u52a8\u56fe\u300124 \u5c0f\u65f6\u52a8\u6001\u5fc3\u7535\u56fe\u76d1\u6d4b\u548c\u8fd0\u52a8\u5fc3\u7535\u56fe\u68c0\u67e5\uff0c\u53ea\u6709\u5728\u5fc3\u810f\u751f\u7269\u6807\u5fd7\u7269\u548c\u708e\u75c7\u6807\u5fd7\u7269\u6062\u590d\u6b63\u5e38\u3001\u5fc3\u5f8b\u5931\u5e38\u6d88\u9000\u548c\u5fc3\u5ba4\u529f\u80fd\u6062\u590d\u6b63\u5e38\u540e\u624d\u80fd\u6062\u590d\u6d3b\u52a8 \uff0837).\u540c\u6837\uff0c\u53d1\u751f\u5de6\u5fc3\u5ba4\u6536\u7f29\u529f\u80fd\u969c\u788d\u7684\u60a3\u8005\u5e94\u6839\u636e\u5f53\u524d\u7684\u5fc3\u529b\u8870\u7aed\u6307\u5357\u8fdb\u884c\u7ba1\u7406\u3002\u5c3d\u7ba1\u7531\u4e8e\u75c5\u6bd2\u5bf9 ACE2 \u53d7\u4f53\u7684\u4eb2\u548c\u529b\uff0c\u6700\u521d\u5bf9\u4f7f\u7528\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20-\u919b\u56fa\u916e\u7cfb\u7edf \uff08RAAS\uff09 \u6291\u5236\u8868\u793a\u62c5\u5fe7\uff0c\u4f46\u5728 COVID-19 \u4f4f\u9662\u60a3\u8005\u4e2d\u7ee7\u7eed\u6216\u505c\u6b62 RAAS \u6291\u5236\u7684\u968f\u673a\u6570\u636e\u663e\u793a\u7ed3\u679c\u6ca1\u6709\u5dee\u5f02 \uff0838\uff09\u3002\u56e0\u6b64\uff0c\u793e\u4f1a\u6307\u5357\u76ee\u524d\u5efa\u8bae\u7ee7\u7eed\u5bf9 COVID-19 \u60a3\u8005\u8fdb\u884c RAAS \u76f8\u5173\u6cbb\u7597 [39]\u3002\u6700\u8fd1\u8fd8\u8c03\u67e5\u4e86\u6dfb\u52a0\u4ed6\u6c40\u7c7b\u836f\u7269\u5bf9 COVID-19 \u5371\u91cd\u60a3\u8005\u7684\u76ca\u5904\uff0c\u5047\u8bbe\u7684\u76ca\u5904\u673a\u5236\u662f\u5b83\u4eec\u7684\u6297\u8840\u6813\u5f62\u6210\u548c\u6297\u708e\u7279\u6027\u3002INSPIRATION-S \u8bd5\u9a8c\u62db\u52df\u4e86\u786e\u8bca COVID-19 \u7684 ICU \u60a3\u8005\uff0c\u5e76\u968f\u673a\u5206\u914d\u60a3\u8005\u63a5\u53d7\u963f\u6258\u4f10\u4ed6\u6c40\u6bcf\u5929 20 \u6beb\u514b\u6216\u5b89\u6170\u5242\u3002\u5f53\u8bc4\u4f30 30 \u5929\u5168\u56e0\u6b7b\u4ea1\u7387\u3001\u9759\u8109\u6216\u52a8\u8109\u8840\u6813\u5f62\u6210\u6216\u4f53\u5916\u819c\u80ba\u6c27\u5408 \uff08ECMO\uff09 \u6cbb\u7597\u7684\u4e3b\u8981\u590d\u5408\u7ec8\u70b9\u65f6\uff0c\u963f\u6258\u4f10\u4ed6\u6c40\u672a\u663e\u793a\u6bd4\u5b89\u6170\u5242\u6709\u4efb\u4f55\u76ca\u5904 \uff0840\uff09\u3002<\/p>\n\n\n\n
\u8840\u6db2\u5b66\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u6025\u6027 COVID-19 \u4e0e\u8840\u6813\u5f62\u6210\u4e8b\u4ef6\u7684\u98ce\u9669\u589e\u52a0\u6709\u5173\uff0c\u5c24\u5176\u662f\u5728\u5371\u91cd\u60a3\u8005\u4e2d \uff0841\uff0c 42\uff09\u3002\u8fd9\u79cd\u51dd\u8840\u75c5\u7684\u75c5\u56e0\u662f\u591a\u56e0\u7d20\u7684\uff0c\u5305\u62ec\u5fae\u8840\u7ba1\u529f\u80fd\u969c\u788d\u548c\u7ec4\u7ec7\u56e0\u5b50\u5bf9\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u53cd\u5e94\u8868\u8fbe\u589e\u52a0\uff0c\u4ee5\u53ca\u7f3a\u6c27\u5bf9\u7f3a\u6c27\u8bf1\u5bfc\u8f6c\u5f55\u56e0\u5b50\u4e0a\u8c03\u7684\u5f71\u54cd \uff0843\uff0c 44\uff09\u3002\u9274\u4e8e\u8be5\u60a3\u8005\u7fa4\u4f53\u4e2d\u8840\u6813\u5f62\u6210\u7684\u98ce\u9669\u589e\u52a0\uff0c\u4e0e\u6807\u51c6\u9884\u9632\u5242\u91cf\u6297\u51dd\u6cbb\u7597\uff08\u4f9d\u8bfa\u809d\u7d20 40 mg \u6bcf\u5929\uff09\u76f8\u6bd4\uff0c\u5e38\u89c4\u4f7f\u7528\u4e2d\u7b49\u5242\u91cf\u6297\u51dd\u5242\uff08\u4f9d\u8bfa\u809d\u7d20 40 mg\/kg\/\u5929\uff09\u5728 INSPIRATION \u8bd5\u9a8c\u4e2d\u4ee5\u968f\u673a\u5bf9\u7167\u65b9\u5f0f\u5728 COVID-19 \u5371\u91cd\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u6d4b\u8bd5\u3002\u4e0e\u6807\u51c6\u9884\u9632\u5242\u91cf\u6297\u51dd\u6cbb\u7597\u76f8\u6bd4\uff0c\u4e2d\u7b49\u5242\u91cf\u6297\u51dd\u6cbb\u7597\u672a\u663e\u793a\u964d\u4f4e\u52a8\u8109\u6216\u9759\u8109\u8840\u6813\u5f62\u6210\u3001ECMO \u6cbb\u7597\u6216 30 \u5929\u6b7b\u4ea1\u7387\u7684\u590d\u5408\u7ec8\u70b9 \uff0845\uff09\u3002\u4e5f\u53ef\u4ee5\u770b\u5230\u51fa\u8840\u4e8b\u4ef6\uff0c\u4f46\u9274\u4e8e\u5927\u51fa\u8840\u7684\u98ce\u9669\u8f83\u4f4e\uff0c\u4f4f\u9662 VTE \u9884\u9632\u7684\u76ca\u5904\u5927\u4e8e\u5927\u591a\u6570\u60a3\u8005\u7684\u98ce\u9669 \uff0846\uff0c 47\uff09\u3002<\/p>\n\n\n\n
\u9ad8\u51dd\u72b6\u6001\u7684\u786e\u5207\u6301\u7eed\u65f6\u95f4\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u5927\u591a\u6570 VTE \u4f3c\u4e4e\u53d1\u751f\u5728\u611f\u67d3\u540e 2-4 \u5468\u5185 \uff0848-50\uff09\u3002\u5df2\u7ecf\u63d0\u8bae\u5c06 COVID-19 \u4f4f\u9662\u60a3\u8005\u7684 VTE \u9884\u9632\u6269\u5c55\u5230\u51fa\u9662\u540e\u5e76\u6269\u5c55\u5230\u95e8\u8bca\uff0c\u4f46\u76ee\u524d\u7684\u6307\u5357\u4e0d\u652f\u6301\u5c06\u5176\u4f5c\u4e3a\u5e38\u89c4\u63aa\u65bd \uff0851\uff09\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u5ef6\u957f\u836f\u7269\u8840\u6813\u9884\u9632\u7684\u6301\u7eed\u65f6\u95f4\u5bf9\u6025\u75c7\u60a3\u8005\u7684\u51c0\u76ca\u5904\u5c1a\u4e0d\u6e05\u695a\uff0c\u56e0\u4e3a\u7814\u7a76\u8868\u660e VTE \u7684\u98ce\u9669\u964d\u4f4e\uff0c\u4f46\u51fa\u8840\u98ce\u9669\u589e\u52a0 \uff0852\uff09\u3002\u4ee3\u8868\u7f8e\u56fd\u80f8\u79d1\u533b\u5e08\u5b66\u4f1a\u7684\u4e13\u5bb6\u5c0f\u7ec4\u8868\u793a\uff0c\u5982\u679c\u5728\u51fa\u9662\u540e 35 \u81f3 42 \u5929\u6709\u75c7\u72b6\u7684 VTE \u53d1\u751f\u7387\u9ad8\u4e8e 1.8%\uff0c\u5219\u9884\u9632\u5bf9\u4f4e\u51fa\u8840\u98ce\u9669\u7684 COVID-19 \u60a3\u8005\u5c06\u6709\u51c0\u76ca\u5904 \uff0853\uff09\uff0c\u4f46\u6839\u636e\u76ee\u524d\u7684\u7814\u7a76\uff0cVTE \u53d1\u751f\u7387\u4f3c\u4e4e\u6ca1\u6709\u8fd9\u4e48\u9ad8\u3002<\/p>\n\n\n\n
\u5728\u56de\u987e\u6027\u7814\u7a76\u4e2d\uff0c\u51fa\u9662\u7684 COVID-19 \u60a3\u8005\u7684 VTE \u53d1\u751f\u7387\u4e3a 0.48% \u81f3 1.9% \uff0848-50\uff0c 54\uff0c 55\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u53d1\u751f\u7387\u53ef\u80fd\u4e0e\u5176\u4ed6\u51fa\u9662\u60a3\u8005\u7fa4\u4f53\u7684\u75c7\u72b6\u6027 VTE \u53d1\u751f\u7387\u76f8\u4f3c \uff0856\uff09\u3002\u5728\u4e00\u9879\u65e8\u5728\u66f4\u597d\u5730\u8bc4\u4f30 COVID-19 \u60a3\u8005\u51fa\u9662\u540e\u8840\u6db2\u5b66\u7ed3\u679c\u7684\u5927\u578b\u524d\u77bb\u6027\u7814\u7a76\u4e2d\uff0cVTE \u7684\u98ce\u9669\u4e3a 1.55%\uff0c\u52a8\u8109\u8840\u6813\u6813\u585e\u7684\u98ce\u9669\u4e3a 1.71%\uff0c\u5927\u51fa\u8840\u7684\u98ce\u9669\u4e3a 1.73%\u3002\u8fd9\u4e9b\u4f5c\u8005\u53d1\u73b0\uff0c\u51fa\u9662\u540e\u836f\u7269\u8840\u6813\u9884\u9632\u5bf9 COVID-19 \u60a3\u8005\u7684\u5168\u56e0\u6b7b\u4ea1\u7387\u3001VTE \u548c\u52a8\u8109\u8840\u6813\u6813\u585e\u7684\u590d\u5408\u5177\u6709\u4fdd\u62a4\u4f5c\u7528;\u4f46\u4f5c\u8005\u6ca1\u6709\u8bc4\u4f30\u8fd9\u4e9b\u5e72\u9884\u63aa\u65bd\u662f\u5426\u663e\u7740\u52a0\u91cd\u4e86\u51fa\u8840 \uff0855\uff09\u3002\u6b63\u5728\u8fdb\u884c\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u66f4\u597d\u5730\u56de\u7b54\u8fd9\u4e2a\u95ee\u9898\uff0c\u5e76\u53ef\u80fd\u63d0\u4f9b\u66f4\u591a\u53ef\u7528\u4e8e\u98ce\u9669\u5206\u5c42\u7684\u4fe1\u606f \uff08NCT04416048\uff0c NCT04508439\uff09\u3002<\/p>\n\n\n\n
\u795e\u7ecf\u7cbe\u795e\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u5b58\u5728\u4e0e SARS-CoV-2 \u611f\u67d3\u76f8\u5173\u7684\u5404\u79cd\u795e\u7ecf\u548c\u7cbe\u795e\u957f\u671f\u5e76\u53d1\u75c7\u3002\u6765\u81ea\u591a\u4e2a\u4e0d\u540c\u6765\u6e90\u7684\u957f\u671f\u75c7\u72b6\u6570\u636e\u62a5\u544a\u4e86\u6025\u6027\u611f\u67d3\u540e 2 \u4e2a\u6708\u60a3\u8005\u6301\u7eed\u7684\u795e\u7ecf\u7cfb\u7edf\u53d1\u73b0\uff0c\u5305\u62ec\u75b2\u52b3\u3001\u808c\u65e0\u529b\u3001\u7761\u7720\u56f0\u96be\u3001\u808c\u75db\u548c\u5934\u75db \uff0818\uff0c 57\uff09\u3002\u8fd9\u4e9b\u75c7\u72b6\u5df2\u6210\u4e3a\u957f\u671f COVID \u7efc\u5408\u5f81\u7684\u6807\u5fd7\u3002\u55c5\u89c9\u548c\u5473\u89c9\u4e27\u5931\u4e5f\u662f SARS-CoV-2 \u611f\u67d3\u7684\u4e00\u4e2a\u7279\u5f81\uff0c\u4e0e\u5176\u4ed6\u75c5\u6bd2\u611f\u67d3\u76f8\u6bd4\uff0c\u5b83\u662f\u72ec\u4e00\u65e0\u4e8c\u7684\u30022 \u4e2a\u6708\u7684\u957f\u671f\u968f\u8bbf\u53d1\u73b0\uff0c11% \u81f3 13.1% \u7684\u60a3\u8005\u6301\u7eed\u5931\u53bb\u5473\u89c9\u548c\u55c5\u89c9 \uff0819\uff0c 57\uff09\u3002\u7531\u4e8e\u4e0e COVID-19 \u76f8\u5173\u7684\u4e25\u91cd\u3001\u5371\u91cd\u75be\u75c5\u548c\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81 \uff08ARDS\uff09 \u7684\u6c89\u91cd\u8d1f\u62c5\uff0c\u53ef\u4ee5\u9884\u671f\u4e0e\u5148\u524d\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684 ARDS \u60a3\u8005\u7c7b\u4f3c\u7684\u8ba4\u77e5\u6270\u52a8\u3002\u5728\u968f\u8bbf 1 \u5e74\u65f6\uff0c\u5176\u4ed6\u539f\u56e0\u5f15\u8d77\u7684 ARDS \u5e78\u5b58\u8005 \uff0813%\uff09 \u3001\u8bed\u8a00\u6d41\u5229\u5ea6 \uff0816%\uff09 \u548c\u6267\u884c\u529f\u80fd \uff0849%\uff09 \u53d7\u635f \uff0858\uff09\u3002<\/p>\n\n\n\n
\u611f\u67d3 SARS-CoV-2 \u7684\u4eba\u4e5f\u4f1a\u7ecf\u5386\u957f\u671f\u7684\u7cbe\u795e\u540e\u9057\u75c7\u3002Huang \u7b49\u4eba \uff0857\uff09 \u62a5\u544a\u4e86 23% \u7684\u7126\u8651\/\u6291\u90c1\u60a3\u8005\u5728 COVID-19 \u4f4f\u9662\u540e\u7684 60 \u5929\u968f\u8bbf\u4e2d\u3002\u5728\u4e00\u9879\u5bf9 402 \u540d COVID-19 \u540e\u51fa\u9662\u7684\u60a3\u8005\u8fdb\u884c\u968f\u8bbf 1 \u4e2a\u6708\u7684\u7814\u7a76\u4e2d\uff0cMazza \u7b49\u4eba \uff0859\uff09 \u62a5\u544a\u4e86\u521b\u4f24\u540e\u5e94\u6fc0\u969c\u788d \uff08PTSD\uff09 \u7684\u53d1\u751f\u7387\u4e3a 28%\uff0c\u6291\u90c1\u4e3a 31%\uff0c\u7126\u8651\u4e3a 42%\uff0c\u5931\u7720\u4e3a 40%\u3002\u5728\u7f8e\u56fd\u8fdb\u884c\u7684\u4e00\u9879\u5927\u89c4\u6a21\u961f\u5217\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u5176\u4ed6\u51e0\u79cd\u5065\u5eb7\u4e8b\u4ef6\uff08\u4f8b\u5982\uff0c\u5176\u4ed6\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u3001\u76ae\u80a4\u611f\u67d3\u3001\u9aa8\u6298\u7b49\uff09\u76f8\u6bd4\uff0c\u611f\u67d3 SARS-CoV-2 \u540e 14 \u81f3 90 \u5929\u5185\u65b0\u7cbe\u795e\u75c5\u8bca\u65ad\u7684\u53d1\u751f\u7387\u589e\u52a0\u3002\uff0860\uff09.<\/p>\n\n\n\n
\u5c31\u50cf\u5728\u5176\u4ed6\u5668\u5b98\u4e2d\u89c2\u5bdf\u5230\u7684\u75c5\u7406\u4e00\u6837\uff0cCOVID-19 \u7684\u795e\u7ecf\u7cfb\u7edf\u5e76\u53d1\u75c7\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7\u4e00\u4e9b\u62df\u8bae\u7684\u673a\u5236\u53d1\u751f\u7684\u3002\u4e00\u4e9b\u63d0\u51fa\u7684\u673a\u5236\u5305\u62ec\u76f4\u63a5\u75c5\u6bd2\u635f\u4f24\u3001\u5168\u8eab\u708e\u75c7\u548c\u8111\u8840\u7ba1\u53d8\u5316\uff0c\u6700\u6709\u53ef\u80fd\u7684\u60c5\u51b5\u6d89\u53ca\u4e0a\u8ff0\u6240\u6709\u60c5\u51b5\u7684\u7ec4\u5408 \uff0861\uff09\u3002\u6d89\u53ca\u7b2c\u4e00\u6b21 SARS-CoV-1 \u6d41\u884c\u7684\u5c38\u68c0\u7814\u7a76\u5728\u5927\u8111\u4e2d\u53d1\u73b0\u4e86\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u5c3d\u7ba1\u8fc4\u4eca\u4e3a\u6b62\u5c1a\u672a\u53d1\u8868\u8bc1\u5b9e SARS-CoV-2 \u4e2d\u76f8\u540c\u53d1\u73b0\u7684\u5c38\u68c0\u7814\u7a76 \uff0862\uff09\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5bf9\u5371\u91cd\u60a3\u8005\u8fdb\u884c SARS-CoV-2 \u7684\u8111\u810a\u6db2\u5206\u6790 RT-PCR \u672a\u80fd\u8bc6\u522b\u75c5\u6bd2 \uff0863\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4ee5\u4e0b\u5047\u8bbe\uff1a\u5168\u8eab\u6027\u708e\u75c7\u635f\u4f24\u5728 SARS-CoV-2 \u611f\u67d3\u540e\u795e\u7ecf\u8ba4\u77e5\u5e76\u53d1\u75c7\u7684\u53d1\u5c55\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528 \uff0861\uff09\u3002\u5173\u4e8e\u55c5\u89c9\u548c\u5473\u89c9\u4e27\u5931\uff0c\u75c5\u7406\u751f\u7406\u5b66\u5c1a\u672a\u660e\u786e\u3002\u53ef\u80fd\u7684\u673a\u5236\u5305\u62ec\u75c5\u6bd2\u5bf9\u55c5\u89c9\u4e0a\u76ae\u4e2d\u55c5\u89c9\u7ec6\u80de\u7684\u76f4\u63a5\u635f\u4f24\uff0c\u4ee5\u53ca\u5bf9\u55c5\u89c9\u4e0a\u76ae\u4e2d\u55c5\u89c9\u548c\u8868\u8fbe ACE2 \u6240\u9700\u7684\u5176\u4ed6\u7ec6\u80de\u7684\u76f4\u63a5\u635f\u4f24 \uff0864\uff09\u3002\u540c\u6837\uff0c\u636e\u63a8\u6d4b\uff0c\u5473\u89c9\u4e27\u5931\u662f\u7531\u4e8e ACE2 \u5728\u53e3\u8154\u7c98\u819c\uff08\u5305\u62ec\u820c\u5934\uff09\u4e0a\u5f25\u6f2b\u6027\u8868\u8fbe\u6240\u81f4 \uff0865\uff09\u3002\u7531\u4e8e\u8fd9\u4e24\u79cd\u611f\u5b98\u662f\u5982\u6b64\u7d27\u5bc6\u5730\u8054\u7cfb\u5728\u4e00\u8d77\uff0c\u4e5f\u6709\u4eba\u8ba4\u4e3a\u55c5\u89c9\u7684\u4e27\u5931\u662f\u5473\u89c9\u4e27\u5931\u7684\u91cd\u8981\u539f\u56e0 \uff0865\uff09\u3002<\/p>\n\n\n\n
\u5bf9\u4e8e\u611f\u67d3 SARS-CoV-2 \u540e\u51fa\u73b0\u795e\u7ecf\u6216\u7cbe\u795e\u75c7\u72b6\u7684\u4efb\u4f55\u60a3\u8005\uff0c\u5e94\u8003\u8651\u4f7f\u7528\u6b63\u5f0f\u7684\u795e\u7ecf\u5fc3\u7406\u5b66\u6d4b\u8bd5\u8fdb\u884c\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002\u5e94\u4f7f\u7528\u7126\u8651\u548c\u6291\u90c1\u7684\u6807\u51c6\u7b5b\u67e5\u5de5\u5177\uff0c\u5e76\u4e13\u95e8\u7b5b\u67e5\u98ce\u9669\u6700\u9ad8\uff08\u5373\u4e25\u91cd\u75be\u75c5\uff09\u7684 PTSD\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u53ef\u80fd\u90e8\u5206\u6709\u52a9\u4e8e\u8ba4\u77e5\u53d1\u73b0 \uff0866\uff09\u3002\u4efb\u4f55\u55c5\u89c9\u548c\u5473\u89c9\u53d7\u635f\u7684\u60a3\u8005\u90fd\u5e94\u8003\u8651\u8fdb\u884c\u55c5\u89c9\u8bad\u7ec3\uff0c\u8fd9\u901a\u5e38\u5305\u62ec\u6bcf\u5929\u66b4\u9732\u4e8e\u5f3a\u70c8\u7684\u6c14\u5473\u4e2d 3 \u4e2a\u6708 \uff0864\uff09\u3002<\/p>\n\n\n\n
\u76ae\u80a4\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u5728\u62a5\u544a\u7684 COVID-19 \u611f\u67d3\u7684\u76ae\u80a4\u8868\u73b0\u4e2d\uff0c\u4e00\u9879\u6587\u732e\u7efc\u8ff0\u53d1\u73b0\uff0c\u5728 18 \u9879\u7814\u7a76\u4e2d\u8bb0\u5f55\u7684 72 \u540d\u60a3\u8005\u4e2d\uff0c\u6709 36.1% \u62a5\u544a\u6591\u4e18\u75b9\uff08\u9ebb\u75b9\u6837\uff09\u662f COVID-19 \u6700\u5e38\u89c1\u7684\u76ae\u80a4\u8868\u73b0\uff0c\u5176\u6b21\u662f\u4e18\u75b9\u76ae\u75b9 \uff0834.7%\uff09\u3001\u8368\u9ebb\u75b9 \uff089.7%\uff09 \u548c\u75bc\u75db\u7684\u7ea2\u8272\u80a2\u7aef\u7d2b\u8272\u4e18\u75b9 \uff0815.3%\uff09\uff0c\u5176\u4e2d 19.4% \u51fa\u73b0\u5728\u624b\u548c\u811a \uff0867).\u53e6\u4e00\u9879\u9488\u5bf9 2,560 \u540d\u60a3\u8005\u7684\u56fd\u9645\u7814\u7a76\u53d1\u73b0\uff0c\u51bb\u75ae\u6837\u75c5\u53d8\u662f\u6700\u5e38\u89c1\u7684\u76ae\u80a4\u8868\u73b0 \uff0851.5%\uff09\uff0c\u513f\u7ae5\u4e0a\u547c\u5438\u9053\u611f\u67d3\u4e0e\u76ae\u80a4\u53d1\u73b0\u4e4b\u95f4\u7684\u6f5c\u4f0f\u671f\u4e3a 1.5 \u5929\uff0c\u6210\u4eba\u4e3a 7.9 \u5929 \uff0868\uff09\u3002\u5728\u4e2d\u56fd\u5bf9\u4f4f\u9662\u60a3\u8005\u7684\u6025\u6027 COVID-19 \u540e\u7814\u7a76\u4e2d\uff0c1,655 \u540d\u60a3\u8005\u4e2d\u53ea\u6709 47 \u540d \uff083%\uff09 \u5728\u611f\u67d3\u53d1\u4f5c\u540e 6 \u4e2a\u6708\u62a5\u544a\u76ae\u75b9 \uff0857\uff09;\u76f8\u53cd\uff0c\u8131\u53d1\u662f\u60a3\u8005\u611f\u67d3 COVID-19 \u6570\u6708\u540e\u66f4\u5e38\u89c1\u7684\u75c7\u72b6\uff0c120 \u540d\u60a3\u8005\u4e2d\u6709 24 \u540d \uff0820.0%\uff09 \u62a5\u544a\u4e3a\u51fa\u9662\u540e 110 \u5929\u7684\u51fa\u9662\u540e\u75c7\u72b6 \uff0869\uff09\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u75c5\u4f8b\u62a5\u544a\u4e2d\u4ecd\u62a5\u544a\u4e86\u5176\u4ed6\u66f4\u7f55\u89c1\u7684\u8868\u73b0\uff0c\u8fd9\u8868\u660e\u5c3d\u7ba1\u611f\u67d3\u4e86\u76f8\u540c\u7684\u75c5\u6bd2\uff0c\u4f46\u4e0d\u540c\u60a3\u8005\u7684\u8868\u73b0\u53ef\u80fd\u4e0d\u540c \uff0870\uff09\u3002\u5c3d\u7ba1\u6709\u4eba\u63d0\u51fa\u6c34\u75b1\u75b9\u53ef\u80fd\u8868\u660e COVID-19 \u7684\u521d\u6b65\u8bca\u65ad\uff0c\u800c\u8840\u7ba1\u75b9\u53ef\u80fd\u8868\u660e\u75be\u75c5\u9884\u540e\uff0c\u4f46\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u51c6\u786e\u4f7f\u7528\u8fd9\u4e9b\u75c7\u72b6\u5c1a\u672a\u5f97\u5230\u9a8c\u8bc1\uff0c\u5e94\u6210\u4e3a\u672a\u6765\u524d\u77bb\u6027\u7814\u7a76\u7684\u4e3b\u9898 \uff0871\uff09\u3002<\/p>\n\n\n\n
\u5c3d\u7ba1\u5176\u4e2d\u8bb8\u591a\u75c7\u72b6\u7684\u786e\u5207\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u5e76\u4e14\u53ef\u80fd\u662f\u7531\u4e8e\u5bfc\u81f4\u957f\u671f COVID-19 \u5176\u4ed6\u75c7\u72b6\u7684\u76f8\u540c\u673a\u5236\uff0c\u4f46\u6709\u4e00\u4e9b\u72ec\u7279\u7684\u75c5\u6bd2\u673a\u5236\u53ef\u80fd\u9002\u7528\u3002\u4f8b\u5982\uff0c\u4f11\u6b62\u671f\u8131\u53d1\u63cf\u8ff0\u4e86\u975e\u7622\u75d5\u6027\u8131\u53d1\u5f62\u5f0f\u7684\u6682\u65f6\u6027\u8131\u53d1\u73b0\u8c61\uff0c\u53d1\u751f\u5728\u4f11\u514b\u3001\u521b\u4f24\u4e8b\u4ef6\u3001\u4ea7\u540e\u8377\u5c14\u8499\u53d8\u5316\u6216\u6025\u6027\u53d1\u70ed\u6027\u75be\u75c5\/\u75c5\u6bd2\u611f\u67d3\u4e4b\u540e\uff0c\u901a\u5e38\u6301\u7eed\u4e0d\u5230 6 \u4e2a\u6708 \uff0872\uff09\u3002\u611f\u67d3 COVID-19 \u540e\u51fa\u73b0\u8131\u53d1\u75c7\u72b6\u7684\u60a3\u8005\u53ef\u80fd\u4f1a\u53d1\u73b0\uff0c\u4f7f\u7528\u7c73\u8bfa\u5730\u5c14\u3001\u975e\u90a3\u96c4\u80fa\u548c\u5916\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u7b49\u836f\u7269\u540e\uff0c\u75c7\u72b6\u662f\u53ef\u9006\u7684 [73]\u3002<\/p>\n\n\n\n
\u5b69\u5b50
\u513f\u7ae5\u88ab\u8bca\u65ad\u51fa\u60a3\u6709 COVID-19 \u7684\u6bd4\u7387\u4f4e\u4e8e\u6210\u4eba\uff0c\u5e76\u4e14\u5728\u6025\u6027\u671f\u7684\u75c5\u60c5\u901a\u5e38\u8f83\u8f7b \uff0874\uff09\u3002\u7136\u800c\uff0c\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7\u5305\u62ec\u513f\u7ae5\u591a\u7cfb\u7edf\u708e\u75c7\u7efc\u5408\u5f81 \uff08MIS-C\uff09\uff0c\u5176\u7279\u5f81\u662f\u5728 SARS-CoV-2 \u611f\u67d3\u540e\u51e0\u5468\u5185\u51fa\u73b0\u53d1\u70ed\u548c\u591a\u5668\u5b98\u529f\u80fd\u969c\u788d \uff0875\uff0c 76\uff09\u3002MIS-C \u7684\u53d1\u75c5\u7387\u4e3a\u6bcf 1,000,000 \u4f8b\u611f\u67d3 316 \u4f8b\uff0c\u4e3b\u8981\u5f71\u54cd\u5c11\u6570\u79cd\u65cf\/\u6c11\u65cf\u80cc\u666f\u7684\u513f\u7ae5 \uff0877\uff0c 78\uff09\u3002MIS-C \u7684\u7279\u5f81\u4e0e\u4e25\u91cd\u6025\u6027 COVID-19 \u548c\u5ddd\u5d0e\u75c5\u91cd\u53e0\uff0c\u8fd1 75% \u7684\u60a3\u8005\u9700\u8981\u5165\u4f4f ICU \uff0877\uff0c 79\uff0c 80\uff09\u3002\u6700\u5e38\u89c1\u7684\u8868\u73b0\u662f\u80c3\u80a0\u9053\u75c7\u72b6\u3001\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u3001\u547c\u5438\u7cfb\u7edf\u75c7\u72b6\u3001\u76ae\u80a4\u7c98\u819c\u8868\u73b0\u548c\u795e\u7ecf\u7cfb\u7edf\u5e76\u53d1\u75c7 \uff0877\uff0c 81\uff09\u3002\u5728\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u4e2d\uff0c\u8fd1\u4e00\u534a\u60a3\u6709\u5fc3\u808c\u708e\uff0c\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\u6709\u6240\u964d\u4f4e\uff0c\u8d85\u8fc7 20% \u60a3\u6709\u51a0\u72b6\u52a8\u8109\u6269\u5f20\u6216\u52a8\u8109\u7624 \uff0877\uff09\u3002\u4e3a\u4e86\u6cbb\u7597 MIS-C\uff0c\u8d85\u8fc7 75% \u7684\u60a3\u8005\u63a5\u53d7\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\uff0c\u8d85\u8fc7\u4e00\u534a\u7684\u60a3\u8005\u9700\u8981\u6b63\u6027\u808c\u529b\u652f\u6301\uff0c1\/4 \u63a5\u53d7\u63d2\u7ba1\uff0c1\/4 \u63a5\u53d7\u65e0\u521b\u901a\u6c14\u3002\u5176\u4ed6\u5e38\u89c1\u7684\u6cbb\u7597\u65b9\u5f0f\u5305\u62ec\u963f\u53f8\u5339\u6797\u3001\u7c7b\u56fa\u9187\u548c\u5176\u4ed6\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u3002\u603b\u4f53\u9884\u540e\u826f\u597d\uff0c\u6b7b\u4ea1\u7387\u4f4e\u81f3 1.9%\uff0c\u901a\u5e38\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u5728\u51e0\u5468\u5185\u6d88\u9000 \uff0877\uff09\u3002\u7136\u800c\uff0c\u5728\u5c11\u6570\u60a3\u8005\u4e00\u4e2a\u591a\u6708\u540e\u4ecd\u53ef\u89c1\u5c04\u8840\u5206\u6570\u6301\u7eed\u964d\u4f4e\u548c\u51a0\u72b6\u52a8\u8109\u7624\u672a\u89e3\u51b3\uff0c\u5e76\u4e14 MIS-C \u7684\u957f\u671f\u540e\u679c\u5c1a\u4e0d\u786e\u5b9a \uff0877\uff0c 80\uff09\u3002<\/p>\n\n\n\n
\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u5148\u524d\u5b58\u5728\u7684\u7cd6\u5c3f\u75c5\u4e0e\u66f4\u7cdf\u7cd5\u7684 COVID-19 \u7ed3\u679c\u6709\u5173\u3002\u540c\u65f6\uff0cCOVID-19 \u4e0e\u65b0\u53d1\u9ad8\u8840\u7cd6\u548c\u7cd6\u5c3f\u75c5\u6025\u6027\u5931\u4ee3\u507f\u6709\u5173\uff0c\u5305\u62ec 1 \u578b\u548c 2 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u7cd6\u5c3f\u75c5\u916e\u75c7\u9178\u4e2d\u6bd2 \uff0882\uff09\u3002\u9664\u4e86\u4f7f\u7528\u7c7b\u56fa\u9187\u5f15\u8d77\u7684\u533b\u6e90\u6027\u9ad8\u8840\u7cd6\u5916\uff0c\u611f\u67d3\u540e\u9ad8\u8840\u7cd6\u7684\u62df\u8bae\u673a\u5236\u5305\u62ec\u708e\u75c7\u72b6\u6001\u5bfc\u81f4\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u4ee5\u53ca\u03b2\u7ec6\u80de\u53d7\u635f\u5f15\u8d77\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u4e0d\u8db3\u2014\u2014\u8981\u4e48\u662f\u7531\u4e8e\u76f4\u63a5\u75c5\u6bd2\u635f\u4f24\uff0c\u8981\u4e48\u662f\u7531\u4e8e\u95f4\u63a5\u5f71\u54cd \uff0882\uff0c 83\uff09\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u6709\u591a\u5c11\u5728 COVID-19 \u540e\u65b0\u8bca\u65ad\u51fa\u60a3\u6709\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u5728\u611f\u67d3\u524d\u5df2\u7ecf\u60a3\u6709\u672a\u88ab\u8bc6\u522b\u7684\u7cd6\u5c3f\u75c5\uff0c\u5e76\u4e14\u53ea\u662f\u66b4\u9732\u4e86\u4ed6\u4eec\u7684\u7cd6\u5c3f\u75c5\u6216\u6076\u5316\u4e86\u4ed6\u4eec\u7684\u7cd6\u5c3f\u75c5\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u56e0 COVID-19 \u4f4f\u9662\u540e\u65b0\u53d1\u7cd6\u5c3f\u75c5\u662f\u5426\u662f\u6c38\u4e45\u6027\u7684\u3002\u56e0\u6b64\uff0c\u521b\u5efa\u4e86\u5168\u7403 CoviDiab \u767b\u8bb0\u5904\uff0c\u4ee5\u8fdb\u4e00\u6b65\u7814\u7a76 COVID-19 \u4e0e\u7cd6\u5c3f\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u66f4\u597d\u5730\u63cf\u8ff0 COVID-19 \u540e\u7cd6\u5c3f\u75c5\u7684\u6301\u7eed\u65f6\u95f4 \uff0884\uff09\u3002<\/p>\n\n\n\n
\u80be\u810f\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u6025\u6027\u80be\u635f\u4f24 \uff08AKI\uff09 \u5728\u6025\u6027 COVID-19 \u4e2d\u5f88\u5e38\u89c1\uff0c5% \u7684\u4f4f\u9662\u60a3\u8005\u9700\u8981\u4f4f\u9662\u80be\u810f\u66ff\u4ee3\u6cbb\u7597 \uff0885\uff09\u3002AKI \u7684\u75c5\u56e0\u662f\u591a\u56e0\u7d20\u7684\uff0c\u5176\u5f71\u54cd\u56e0\u7d20\u5305\u62ec\u76f4\u63a5\u75c5\u6bd2\u635f\u4f24\u3001\u5168\u8eab\u6027\u7f3a\u6c27\u3001\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u5f71\u54cd\u548c\u5f02\u5e38\u51dd\u8840 \uff0886\u201389\uff09\u3002\u6025\u6027\u80be\u5c0f\u7ba1\u574f\u6b7b\u662f\u6700\u5e38\u89c1\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u53d1\u73b0\uff0c\u4f46\u4e5f\u53ef\u89c1\u80be\u5c0f\u7403\u75c5\u548c\u5fae\u8840\u7ba1\u8840\u6813 \uff0887-93\uff09\u3002AKI \u4e0e\u4f4f\u9662\u6b7b\u4ea1\u7387\u589e\u52a0\u6709\u5173\uff0c\u51fa\u9662\u540e\u5b58\u6d3b\u8005\u53ef\u80fd\u6709\u6b8b\u4f59\u80be\u529f\u80fd\u4e0d\u5168 \uff0885\uff09\u3002\u5728\u4e00\u9879\u56de\u987e\u6027\u7814\u7a76\u4e2d\uff0c35% \u7684 AKI \u60a3\u8005\u5728\u51fa\u9662\u65f6\u4ecd\u5b58\u5728\u80be\u529f\u80fd\u5f02\u5e38\uff0c30% \u9700\u8981\u4f4f\u9662\u900f\u6790\u7684\u60a3\u8005\u5728\u51fa\u9662\u540e\u7ee7\u7eed\u9700\u8981\u900f\u6790\u3002\u5728\u540c\u4e00\u9879\u7814\u7a76\u7684\u968f\u8bbf\u4e2d\uff08\u4e2d\u4f4d 21 \u5929\uff09\uff0c\u51fa\u9662\u65f6\u6709\u6b8b\u7559\u80be\u75c5\u7684\u60a3\u8005\u4e2d\u6709 36% \u5df2\u7ecf\u5eb7\u590d\uff0c\u4f46\u51fa\u9662\u524d\u5eb7\u590d\u7684\u60a3\u8005\u4e2d\u6709 14% \u60a3\u6709\u590d\u53d1\u6027\u80be\u75c5 \uff0894\uff09\u3002\u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0c35% \u7684 COVID-19 \u5e78\u5b58\u8005\u5728 6 \u4e2a\u6708\u65f6\u51fa\u73b0\u80be\u529f\u80fd\u4e0d\u5168\uff0c13% \u5728\u521d\u6b21\u60a3\u75c5\u671f\u95f4\u80be\u529f\u80fd\u6b63\u5e38\u540e\u51fa\u73b0\u65b0\u53d1\u80be\u529f\u80fd\u4e0d\u5168 \uff0857\uff09\u3002\u9274\u4e8e\u4e0e\u5bc6\u5207\u968f\u8bbf\u76f8\u5173\u7684\u7ed3\u679c\u6539\u5584\uff0c\u6025\u6027 COVID-19 \u540e\u80be\u75c5\u60a3\u8005\u5e94\u4e0e\u80be\u75c5\u4e13\u5bb6\u5efa\u7acb\u62a4\u7406 \uff0895\uff0c 96\uff09\u3002<\/p>\n\n\n\n
\u80c3\u80a0\u9053\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u80c3\u80a0\u9053\u75c7\u72b6\u5728\u6025\u6027 COVID-19 \u4e2d\u5f88\u5e38\u89c1\uff0c\u5728\u540e\u6765\u7684\u5eb7\u590d\u4e2d\u4e5f\u4f1a\u51fa\u73b0\u3002\u5728\u4e00\u9879\u5173\u4e8e\u6025\u6027 COVID-19 \u540e\u8868\u73b0\u7684\u7cfb\u7edf\u8bc4\u4ef7\u4e2d\uff0c\u8179\u6cfb\u662f\u524d 10 \u5927\u6700\u5e38\u89c1\u7684\u4e3b\u8bc9\u4e4b\u4e00\uff0c\u60a3\u75c5\u7387\u4e3a 6%\u3002\u5176\u4ed6\u957f\u671f\u75c7\u72b6\u5305\u62ec\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u75db\u548c\u98df\u6b32\u4e0d\u632f \uff0897\uff09\u3002\u8fd9\u4e9b\u6301\u7eed\u7684\u75c7\u72b6\u53ef\u80fd\u4e0e\u80c3\u80a0\u9053\u4e2d\u6301\u7eed\u7684\u75c5\u6bd2\u590d\u5236\u6709\u5173\uff0c\u56e0\u4e3a\u5373\u4f7f\u5728\u547c\u5438\u9053\u6837\u672c\u53d8\u4e3a\u9634\u6027\u540e\uff0cSARS-CoV-2 \u7684\u7caa\u4fbf\u6392\u51fa\u65f6\u95f4\u4e5f\u4f1a\u5ef6\u957f \uff0898-101\uff09\u3002COVID-19 \u4e5f\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u6539\u53d8\u6709\u5173\uff0c\u5c3d\u7ba1\u8fd9\u5bf9\u957f\u671f\u75c7\u72b6\u7684\u5f71\u54cd\u5c1a\u4e0d\u6e05\u695a \uff08102\uff0c 103\uff09\u3002<\/p>\n\n\n\n
\u809d\u529f\u80fd\u68c0\u67e5\u5f02\u5e38\u5e38\u89c1\u4e8e\u6025\u6027\u671f\uff0c\u5bf9\u5e94\u4e8e\u809d\u7ec6\u80de\u635f\u4f24\u548c\/\u6216\u80c6\u6c41\u6de4\u6ede \uff08104\uff0c 105\uff09\u3002\u635f\u4f24\u673a\u5236\u5305\u62ec\u76f4\u63a5\u75c5\u6bd2\u7ec6\u80de\u6bd2\u6027\uff0c\u7279\u522b\u662f\u5728\u80c6\u9053\u6811\u4e2d\uff0c\u4ee5\u53ca\u5168\u8eab\u708e\u75c7\u3001\u7f3a\u6c27\u3001\u51dd\u8840\u75c5\u548c\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u5f71\u54cd \uff08105\u2013108\uff09\u3002\u5728\u5c38\u68c0\u7814\u7a76\u4e2d\uff0c\u5e38\u89c1\u7684\u53d1\u73b0\u5305\u62ec\u809d\u8102\u80aa\u53d8\u6027\u3001\u809d\u5145\u8840\u3001\u8840\u7ba1\u8840\u6813\u5f62\u6210\u3001\u7ea4\u7ef4\u5316\u3001\u95e8\u9759\u8109\u708e\u548c\u5c0f\u53f6\u708e \uff08109\uff09\u3002\u5728\u60a3\u6709\u6025\u6027\u809d\u635f\u4f24\u7684 COVID-19 \u5e78\u5b58\u8005\u4e2d\uff0c\u809d\u529f\u80fd\u5f02\u5e38\u53ef\u80fd\u4f1a\u6301\u7eed\u5b58\u5728\uff0c\u4f46\u5728\u6570\u5468\u81f3\u6570\u6708\u5185\u9010\u6e10\u6539\u5584 \uff08106\uff09\u3002<\/p>\n\n\n\n
\u808c\u8089\u9aa8\u9abc\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u808c\u8089\u9aa8\u9abc\u75c7\u72b6\u662f COVID-19 \u6700\u5e38\u89c1\u7684\u4e3b\u8bc9\u4e4b\u4e00\uff0c\u65e0\u8bba\u662f\u5728\u75be\u75c5\u53d1\u4f5c\u65f6\u8fd8\u662f\u5728\u6025\u6027\u671f\u540e \uff0897\uff0c 110\uff0c 111\uff09\u3002\u4e0d\u51fa\u6240\u6599\uff0cACE 2 \u53d7\u4f53\u5b58\u5728\u4e8e\u9aa8\u9abc\u808c\u548c\u6ed1\u819c\u7ec4\u7ec7\u4e2d\uff0c\u8868\u660e\u75c5\u6bd2\u4fb5\u5165\u8fd9\u4e9b\u7ec4\u7ec7\u4f1a\u5bfc\u81f4\u75c7\u72b6 \uff08112\uff09\u3002\u5c3d\u7ba1\u5173\u8282\u708e\u4e0e\u4e00\u4e9b\u75c5\u6bd2\u6027\u75be\u75c5\u6709\u5173\uff0c\u4f46 COVID-19 \u66f4\u5178\u578b\u5730\u5bfc\u81f4\u808c\u75db\u548c\u5173\u8282\u75db\uff0c\u800c\u6ca1\u6709\u771f\u6b63\u7684\u708e\u75c7\u6027\u5173\u8282\u708e \uff08113\uff0c 114\uff09\u3002COVID-19 \u540e\u65b0\u53d1\u98ce\u6e7f\u75c5\u7684\u62a5\u544a\u4e3b\u8981\u9650\u4e8e\u75c5\u4f8b\u62a5\u544a \uff08114\uff09\u3002\u4e0e\u5176\u4ed6\u5371\u91cd\u75be\u75c5\u4e0d\u540c\uff0c\u4e25\u91cd COVID-19 \u7684\u4e00\u4e2a\u4e3b\u8981\u5e76\u53d1\u75c7\u662f\u7531\u4e8e\u5168\u8eab\u708e\u75c7\u3001\u957f\u671f\u5367\u5e8a\u4f11\u606f\u548c\u8425\u517b\u4e0d\u826f\u800c\u5bfc\u81f4\u7684\u5206\u89e3\u4ee3\u8c22\u808c\u8089\u840e\u7f29 \uff08115\uff09\u3002\u5371\u91cd\u75be\u75c5\u540e\u7684\u8eab\u4f53\u635f\u4f24\u53ef\u80fd\u6301\u7eed\u6570\u6708\u751a\u81f3\u6570\u5e74 \uff08116\uff09;\u5728 COVID-19 \u7684\u5e78\u5b58\u8005\u4e2d\uff0c\u90a3\u4e9b\u60a3\u6709\u66f4\u4e25\u91cd\u6025\u6027\u75be\u75c5\u7684\u4eba\u5728 6 \u4e2a\u6708\u968f\u8bbf\u65f6\u808c\u8089\u65e0\u529b\u3001\u884c\u52a8\u4e0d\u4fbf\u3001\u6b65\u884c\u8ddd\u79bb\u66f4\u77ed \uff0857\uff09\u3002\u8fd9\u51f8\u663e\u4e86\u5728 COVID-19 \u7684\u65e9\u671f\u548c\u6025\u6027\u671f\u540e\u4f18\u5316\u8425\u517b\u548c\u5eb7\u590d\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n
\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u5e76\u53d1\u75c7\u548c\u540e\u9057\u75c7
\u75c7\u72b6\u540e COVID-19 \u60a3\u8005\u901a\u5e38\u6ca1\u6709\u63cf\u8ff0\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u75c7\u72b6;\u7136\u800c\uff0c\u5c24\u5176\u662f\u7537\u6027\u4e0d\u80b2\u75c7\uff0c\u53ef\u80fd\u5f15\u53d1\u4e86 COVID-19 \u611f\u67d3\u7684\u957f\u671f\u5065\u5eb7\u95ee\u9898 \uff08117\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5df2\u5728\u53d7\u611f\u67d3\u7537\u6027\u7684\u7cbe\u6db2\u4e2d\u68c0\u6d4b\u5230\u75c5\u6bd2 mRNA\uff0c\u6709\u8bc1\u636e\u8868\u660e\uff0c\u7531\u4e8e ACE2 \u53d7\u4f53\u8868\u8fbe\u589e\u52a0\uff0c\u7537\u6027\u6027\u817a\u4e5f\u53ef\u80fd\u7279\u522b\u654f\u611f \uff088\uff0c 118\uff09\u3002\u7814\u7a76\u8fd8\u663e\u793a\uff0c\u777e\u916e\u548c\u4e8c\u6c22\u777e\u916e\u4ee5\u53ca\u4e00\u4e9b\u60a3\u8005\u7684\u777e\u4e38\u75c5\u7406\u708e\u75c7\u4f53\u5f81\u663e\u7740\u964d\u4f4e\uff0c\u636e\u62a5\u9053\uff0c\u75c5\u6bd2\u6027\u777e\u4e38\u708e\u7684\u53d1\u75c5\u7387\u9ad8\u8fbe 19% \uff08118\uff0c 119\uff09\u3002\u5728\u5973\u6027\u60a3\u8005\u4e2d\uff0c\u5df2\u7ecf\u63d0\u51fa\u4e86\u5173\u4e8e\u9ec4\u4f53\u751f\u6210\u7d20\u5347\u9ad8\u4ee5\u53ca\u65e9\u4ea7\u800c\u6ca1\u6709\u5782\u76f4\u4f20\u64ad\u98ce\u9669\u7684\u5efa\u8bae\uff0c\u4f46\u662f\uff0c\u9700\u8981\u66f4\u5927\u89c4\u6a21\u7684\u7814\u7a76\u6765\u66f4\u597d\u5730\u4e86\u89e3\u8fd9\u4e9b\u5047\u8bbe\u7684\u6709\u6548\u6027 \uff08118\uff0c 120\uff09\u3002<\/p>\n\n\n\n
\u672a\u6765\u7814\u7a76
\u5728 COVID-19 \u5927\u6d41\u884c\u4e2d\uff0c\u6709\u8bb8\u591a\u8003\u8651\u56e0\u7d20\u5c1a\u672a\u89e3\u51b3\u3002\u6b63\u5982\u5927\u6d41\u884c\u521d\u671f\u6240\u62c5\u5fc3\u7684\u90a3\u6837\uff0c\u65e0\u6cd5\u63a7\u5236\u75c5\u6bd2\u5bfc\u81f4\u4e86\u75c5\u6bd2\u65b0\u53d8\u79cd\u7684\u51fa\u73b0\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u9996\u6b21\u5728\u5370\u5ea6\u53d1\u73b0\u7684 Delta\uff08B.1.617.2 \u8c31\u7cfb\uff09\u53d8\u4f53\u3001\u9996\u6b21\u5728\u5df4\u897f\u53d1\u73b0\u7684 Gamma\uff08P.1 \u8c31\u7cfb\uff09\u548c\u9996\u6b21\u5728\u79d8\u9c81\u53d1\u73b0\u7684 Lambda\uff08C.37 \u8c31\u7cfb\uff09\u53d8\u4f53 \uff082\uff09\u3002\u5176\u4e2d\u4e00\u4e9b\u65b0\u53d8\u4f53\u4e5f\u88ab\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u89c6\u4e3a\u611f\u5174\u8da3\u7684\u53d8\u4f53 \uff08VOI\uff09\uff0c\u8fd9\u8868\u660e\u6cbb\u7597\u6216\u75ab\u82d7\u63a5\u79cd\u5728\u4e2d\u548c\u75c5\u6bd2\u65b9\u9762\u7684\u6709\u6548\u6027\u964d\u4f4e\u3002Delta \u53d8\u4f53\u5df2\u663e\u7740\u5f00\u59cb\u5728\u7f8e\u56fd\u4f20\u64ad\uff0c\u5373\u4f7f\u5728\u63a5\u79cd\u75ab\u82d7\u7684\u4e2a\u4f53\u4e2d\u4e5f\u53d1\u73b0\u4e86\u8bb8\u591a\u7a81\u7834\u6027\u75c5\u4f8b\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e Delta \u53d8\u4f53\u80fd\u591f\u90e8\u5206\uff08\u4f46\u4e0d\u80fd\u5b8c\u5168\uff09\u907f\u514d\u5bf9 SARS-CoV-2 \u7684\u514d\u75ab\u529b\u5f15\u8d77\u7684\u4e2d\u548c\u5355\u514b\u9686\u6216\u591a\u514b\u9686\u6297\u4f53\uff0c\u65e0\u8bba\u662f\u901a\u8fc7\u63a5\u79cd\u75ab\u82d7\u8fd8\u662f\u4ee5\u524d\u7684\u611f\u67d3 \uff083\uff09\u3002<\/p>\n\n\n\n
\u9274\u4e8e\u8fd9\u4e9b\u65b0\u53d8\u79cd\u7684\u53d1\u75c5\u76f8\u5bf9\u8f83\u665a\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u957f\u671f COVID-19 \u7684\u8868\u73b0\u5c06\u5982\u4f55\u5f71\u54cd\u611f\u67d3\u8fd9\u4e9b\u75c5\u6bd2\u682a\u7684\u4e2a\u4f53\u3002\u6700\u8fd1\u7206\u53d1\u7684 Delta \u53d8\u4f53\u4e0d\u5141\u8bb8\u5c31\u75c7\u72b6\u8868\u73b0\u548c\u60a3\u8005\u968f\u8bbf\u968f\u65f6\u95f4\u7684\u5dee\u5f02\u8fdb\u884c\u5927\u578b\u5df2\u53d1\u8868\u7684\u7814\u7a76\u3002\u7136\u800c\uff0cKang \u7b49\u4eba \uff08121\uff09 \u5bf9\u4e2d\u56fd Delta \u53d8\u4f53\u7684\u5206\u6790\u7684\u9884\u5370\u672c\u6307\u51fa\uff0c\u9274\u4e8e\u75c7\u72b6\u524d\u75c5\u6bd2\u8f7d\u91cf\u8f83\u9ad8\uff0c\u643a\u5e26\u8be5\u6bd2\u682a\u7684\u4e2a\u4f53\u66f4\u6709\u53ef\u80fd\u4f20\u64ad\u75c5\u6bd2\uff0c73.9% \u7684 Delta \u75c5\u4f8b\u4f20\u64ad\u53d1\u751f\u5728\u75c7\u72b6\u51fa\u73b0\u4e4b\u524d\u3002\u7136\u800c\uff0c\u5728\u8fd9\u4e9b\u4e2a\u4f53\u4e2d\uff0c\u75ab\u82d7\u63a5\u79cd\u4f3c\u4e4e\u4ecd\u7136\u6709\u6548\uff0c\u56e0\u4e3a\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u4e2a\u4f53 \uff08OR\uff1a 2.84\uff09 \u6216\u4ec5\u63a5\u79cd\u4e00\u5242\u75ab\u82d7\u7684\u4e2a\u4f53 \uff08OR\uff1a 6.02\uff09 \u6bd4\u63a5\u79cd\u4e24\u5242\u75ab\u82d7\u7684\u63a5\u53d7\u8005\u66f4\u6709\u53ef\u80fd\u4f20\u64ad\u611f\u67d3\u3002\u8fd9\u4e9b\u6309\u5e74\u9f84\u548c\u79cd\u65cf\u5206\u5c42\u7684\u65b0\u53d8\u5f02\u60a3\u8005\u75c7\u72b6\u7684\u5177\u4f53\u60c5\u51b5\u4ecd\u6709\u5f85\u89c2\u5bdf\uff0c\u5e76\u5c06\u53d6\u51b3\u4e8e\u66f4\u5927\u89c4\u6a21\u7684\u7814\u7a76\u3002<\/p>\n\n\n\n
\u6700\u540e\uff0c\u5148\u524d\u5bf9\u75c5\u6bd2 Alpha \u53d8\u4f53\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728\u63a5\u53d7\u6cbb\u7597\u3001\u75c7\u72b6\u6301\u7eed\u65f6\u95f4\u3001\u611f\u67d3 COVID-19 \u7684\u53ef\u80fd\u6027\u4ee5\u53ca\u957f\u671f COVID-19 \u75c7\u72b6\u65b9\u9762\u5b58\u5728\u79cd\u65cf\u5dee\u5f02 \uff085\uff09\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9b\u5dee\u5f02\u662f\u7531\u4e8e\u63a5\u53d7\u7684\u62a4\u7406\u5dee\u5f02\uff0c\u8fd8\u662f\u7531\u4e8e\u67d0\u4e9b\u4e2a\u4f53\u53ef\u80fd\u66f4\u5bb9\u6613\u51fa\u73b0\u957f\u671f\u75c7\u72b6\u7684\u5206\u5b50\u673a\u5236\u3002\u8fd9\u4e9b\u65b0\u83cc\u682a\u5bf9\u957f\u671f COVID-19 \u53d1\u5c55\u7684\u5f71\u54cd\u4ee5\u53ca\u54ea\u4e9b\u60a3\u8005\u5c06\u53d7\u5230\u6700\u5927\u5f71\u54cd\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n\n\n\n
\u62e8\u6b3e
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\u62ab\u9732
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