\u4e34\u5e8a\u8868\u73b0\u548c\u8bca\u65ad<\/p>\n\n\n\n
\u4eba\u53e3\u7edf\u8ba1<\/p>\n\n\n\n
\u6839\u636e\u5927\u91cf\u5df2\u53d1\u8868\u7684\u7814\u7a76\uff0c\u60a3\u8005\u5e74\u9f84\u4e2d\u4f4d\u6570\u4e3a 56 \u5c81\uff08\u8303\u56f4\uff1a55-65 \u5c81\uff09\uff0c\u7537\u6027\u4e3b\u8981\u56e0\u4f53\u5185 ACE2 \u6d53\u5ea6\u9ad8\u800c\u53d7\u5230\u5f71\u54cd\u3002\u53d1\u75c5\u4e2d\u4f4d\u6570\u4e3a 8 \u5929\uff08\u8303\u56f4\uff1a5-13 \u5929\uff09\u300246 47\u7531\u4e8e\u5408\u5e76\u75c7\u6570\u636e\u6709\u9650\uff0c\u56e0\u6b64 \u5c06\u5176\u4e0e\u5148\u524d\u5df2\u8bc1\u5b9e\u7684 SARS \u548c MERS-CoV \u611f\u67d3\u6613\u611f\u56e0\u7d20\u5173\u8054\u8d77\u6765\u975e\u5e38\u91cd\u8981\uff0c\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u5438\u70df\u3001\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\/\u6216\u6162\u6027\u75be\u75c5\u300216 24 25 \u6839\u636e\u610f\u5927\u5229\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u6240\u7684\u5206\u6790\uff0cCOVID-19 \u60a3\u8005\u7684\u5e73\u5747\u6b7b\u4ea1\u5e74\u9f84\u4e3a 81 \u5c81\u300248\u5728\u4e2d\u56fd\uff0c\u75c5\u6b7b\u7387 (CFR) \u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u589e\u52a0\uff0c80 \u5c81\u4ee5\u4e0a\u60a3\u8005\u7684 CFR \u4e3a 18%\u300249\u8001\u5e74\u4eba\u7fa4\u51fa\u73b0\u8fd9\u4e00\u60ca\u4eba\u6570\u5b57\u662f\u7531\u4e8e\u6f5c\u5728\u7684\u6162\u6027\u75be\u75c5\u548c\u514d\u75ab\u529f\u80fd\u4e0b\u964d\u3002\u514d\u75ab\u529f\u80fd\u4e0b\u964d\u4e0e\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7efc\u5408\u5f81\uff08\u5faa\u73af\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u5347\u9ad8\uff09\u548c\u9ad8\u708e\u75c7\u7efc\u5408\u5f81\u6709\u5173\u3002\u8fd9\u4e9b\u7efc\u5408\u5f81\u7531\u75c5\u6bd2\u611f\u67d3\u5f15\u53d1\uff0c\u4e5f\u662f COVID-19 \u60a3\u8005\u6b7b\u4ea1\u7684\u9884\u6d4b\u56e0\u7d20\u300250 51 \u513f\u7ae5\u53d7\u611f\u67d3\u7a0b\u5ea6\u8f83\u4f4e\uff0c\u56e0\u4e3a\u4ed6\u4eec\u4f53\u5185\u6297\u4f53\u6c34\u5e73\u8f83\u9ad8\u3001\u65e2\u5f80\u75c5\u6bd2\u66b4\u9732\u53f2\u8f83\u5c11\uff0c\u4e14\u4f53\u5185\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u76f8\u5bf9\u8f83\u4f4e\u3002<\/p>\n\n\n\n
\u4f53\u5f81\u548c\u75c7\u72b6<\/p>\n\n\n\n
\u4e34\u5e8a\u7279\u5f81\u4ece\u8f7b\u5ea6\u75be\u75c5\u5230\u91cd\u5ea6\u6216\u81f4\u547d\u75be\u75c5\u4e0d\u7b49\u3002COVID-19 \u7684\u6700\u5e38\u89c1\u75c7\u72b6\u65e0\u7279\u5f02\u6027\uff0c\u4e3b\u8981\u5305\u62ec\u53d1\u70e7\u3001\u54b3\u55fd\u548c\u808c\u75db\u3002\u5176\u4ed6\u8f7b\u5fae\u75c7\u72b6\u5305\u62ec\u54bd\u5589\u75db\u3001\u5934\u75db\u3001\u53d1\u51b7\u3001\u6076\u5fc3\u6216\u5455\u5410\u3001\u8179\u6cfb\u3001\u5473\u89c9\u4e27\u5931\u548c\u7ed3\u819c\u5145\u8840\u3002COVID-19 \u4e34\u5e8a\u4e0a\u5206\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u75be\u75c5\uff08\u975e\u80ba\u708e\u548c\u80ba\u708e\uff09\u3001\u91cd\u5ea6\u75be\u75c5\uff08\u547c\u5438\u56f0\u96be\u3001\u547c\u5438\u9891\u7387\u8d85\u8fc7 30 \u6b21\/\u5206\u949f\u3001\u8840\u6c27\u9971\u548c\u5ea6\u4f4e\u4e8e 93%\u3001PaO 2 \/FiO 2\u6bd4\u503c\u4f4e\u4e8e 300 \u548c\/\u6216 24-48 \u5c0f\u65f6\u5185\u80ba\u90e8\u6d78\u6da6\u8d85\u8fc7 50% \u7684\u80ba\u91ce\uff09\u548c\u5371\u91cd\u75c7\uff08\u547c\u5438\u8870\u7aed\u3001\u611f\u67d3\u6027\u4f11\u514b\u548c\/\u6216\u591a\u5668\u5b98\u529f\u80fd\u969c\u788d\/\u8870\u7aed\uff09\u300212 52\u8bb8\u591a\u60a3\u6709\u91cd\u75c7\u7684\u8001\u5e74\u60a3\u8005\u6709\u6162\u6027\u6f5c\u5728\u75be\u75c5\u7684\u8bc1\u636e \uff0c\u4f8b\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80ba\u90e8\u75be\u75c5\u3001\u80be\u810f\u75be\u75c5\u6216\u6076\u6027\u80bf\u7624\u300253<\/p>\n\n\n\n
\u5b9e\u9a8c\u5ba4\u8bc4\u4f30\u4e0e\u786e\u8ba4<\/p>\n\n\n\n
\u4e0eCOVID-19\u6700\u76f8\u7b26\u7684\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u662f\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u3001C\u53cd\u5e94\u86cb\u767d\u5347\u9ad8\u548c\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\u5347\u9ad8\u3002\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u662f\u7531\u4e8e\u6dcb\u5df4\u7ec6\u80de\u574f\u6b7b\u6216\u51cb\u4ea1\u5f15\u8d77\u7684\u3002\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u7684\u4e25\u91cd\u7a0b\u5ea6\u53cd\u6620\u4e86COVID-19\u7684\u4e25\u91cd\u7a0b\u5ea6\u300254\u201356\u5728\u5927\u591a\u6570\u5df2\u62a5\u544a\u7684\u513f\u79d1\u75c5\u4f8b\u4e2d\uff0c\u964d\u9499\u7d20\u539f\u901a\u5e38\u5347\u9ad8\uff0c\u5e76\u4e14\u4e0e\u5408\u5e76\u611f\u67d3\u6709\u5173\u300257 58 <\/p>\n\n\n\n
COVID-19 \u7684\u68c0\u6d4b\u57fa\u4e8e\u4f7f\u7528\u62ed\u5b50\uff08\u9f3b\u54bd\u3001\u53e3\u54bd\uff09\u3001\u75f0\u548c\u7caa\u4fbf\u8fdb\u884c RT-PCR \u75c5\u6bd2\u5b66\u68c0\u6d4b\u3001\u80f8\u7247\u548c\u708e\u75c7\u4ecb\u8d28\uff08\u4f8b\u5982\u7ec6\u80de\u56e0\u5b50\uff09\u7684\u52a8\u6001\u76d1\u6d4b\u300259\u201361\u68c0\u6d4b\u7caa\u4fbf\u6837\u672c\u7684 COVID-19 \u6838\u9178\u4e0e\u54bd\u62ed\u5b50\u6837\u672c\u540c\u6837\u51c6\u786e\u300260 COVID- 19\u60a3\u8005\u8840\u6db2\u4e2d\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u6c34\u5e73\u8f83\u9ad8\uff0c\u4f8b\u5982\u767d\u7ec6\u80de\u4ecb\u7d20 (IL)-7\u3001IL-8\u3001IL-9\u3001 IL -10\u3001\u7c92\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u3001\u7c92\u7ec6\u80de\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50 \u03b1 \u548c VEGFA\u300250 62 63 <\/p>\n\n\n\n
\u653e\u5c04\u5b66\u53d1\u73b0<\/p>\n\n\n\n
\u80f8\u90e8CT\u626b\u63cf\u6700\u5e38\u89c1\u7684\u5178\u578b\u8868\u73b0\u662f\u6bdb\u73bb\u7483\u5f71\u3001\u8fb9\u754c\u4e0d\u6e05\u3001\u5149\u6ed1\u6216\u4e0d\u89c4\u5219\u7684\u5c0f\u53f6\u95f4\u9694\u589e\u539a\u3001\u652f\u6c14\u7ba1\u5145\u6c14\u5f81\u3001\u94fa\u8def\u77f3\u5f81\u4ee5\u53ca\u90bb\u8fd1\u80f8\u819c\u589e\u539a\u3002\u80f8\u90e8CT\u88ab\u8ba4\u4e3a\u662fCOVID-19\u7684\u5e38\u89c4\u5f71\u50cf\u5b66\u68c0\u67e5\uff0c\u7075\u654f\u5ea6\u8f83\u9ad8\u300264\u201366<\/p>\n\n\n\n
\u7ba1\u7406<\/p>\n\n\n\n
\u5728\u51fa\u73b0\u805a\u96c6\u6027\u611f\u67d3\u7684\u521d\u671f\uff0c\u8bb8\u591a\u75c5\u4f8b\u63a5\u53d7\u4e86\u6297\u75c5\u6bd2\u6cbb\u7597\u3001\u6297\u83cc\u6cbb\u7597\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5bf9\u4e8e\u8f7b\u5ea6\u60a3\u8005\uff0c\u89c2\u5bdf\u662f\u4e3b\u8981\u6cbb\u7597\u624b\u6bb5\u3002\u60a3\u6709\u6f5c\u5728\u6162\u6027\u75be\u75c5\u3001\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u548c\u598a\u5a20\u7684\u4e2d\u5ea6\u60a3\u8005\u9700\u8981\u4f4f\u9662\u6cbb\u7597\u300267 68 <\/p>\n\n\n\n
\u6297\u759f\u75be\u836f\u7269\u7f9fqlv\u548cqlv\u5728\u65e9\u671f\u4f53\u5916\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6548\u679c\u300269\u7136\u800c\uff0c\u6700\u8fd1\u5bf9 COVID-19 \u60a3\u8005\u8fdb\u884c\u7684\u6700\u6709\u529b\u7814\u7a76\u5e76\u672a\u663e\u793a\u4f7f\u7528\u7f9fqlv\u6216qlv\u6cbb\u7597\u6709\u76ca\u7684\u660e\u786e\u8bc1\u636e\u300270\u201372\u4e8b\u5b9e\u4e0a\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5bf9\u4f7f\u7528\u8fd9\u4e9b\u6297\u759f\u75be\u836f\u7269\u6cbb\u7597 COVID-19 \u60a3\u8005\u7684\u98ce\u9669\u548c\u76ca\u5904\u8fdb\u884c\u7684\u6700\u5927\u89c4\u6a21\u5206\u6790\u65e0\u6cd5\u8bc1\u5b9e\u7f9fqlv\u6216qlv\u5355\u72ec\u4f7f\u7528\u6216\u4e0e\u5927\u73af\u5185\u916f\u7c7b\u836f\u7269\u4e00\u8d77\u4f7f\u7528\u5bf9 COVID-19 \u4f4f\u9662\u7ed3\u679c\u6709\u76ca\u300270\u6b64\u5916\uff0c\u8fd9\u9879\u5bf9\u516d\u5927\u6d32 96,000 \u540d\u4f4f\u9662\u60a3\u8005\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u672a\u4f7f\u7528\u8fd9\u4e9b\u836f\u7269\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u4f7f\u7528\u8fd9\u4e9b\u836f\u7269\u7684\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u660e\u663e\u8f83\u9ad8\uff0c\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u7684\u53d1\u751f\u7387\u4e5f\u8f83\u9ad8\u300270<\/p>\n\n\n\n
COVID-19\u5168\u8eab\u5e76\u53d1\u75c7\u7684\u6cbb\u7597<\/p>\n\n\n\n
\u5bf9\u4e8e\u8fdb\u5c55\u4e3a\u547c\u5438\u8870\u7aed\u7684\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81 (ARDS) \u60a3\u8005\uff0c\u4f53\u5916\u819c\u80ba\u6c27\u5408 (ECMO) \u662f\u6781\u4f73\u7684\u9009\u62e9\u3002\u5176\u4ed6\u6cbb\u7597\u65b9\u5f0f\u5305\u62ec\u9ad8\u6d41\u91cf\u9f3b\u6c27\u548c\u6c14\u7ba1\u63d2\u7ba1\u3002\u6301\u7eed\u6027\u987d\u56fa\u6027\u4f4e\u6c27\u8840\u75c7\u60a3\u8005\u9700\u91c7\u53d6\u4fef\u5367\u4f4d\uff0c\u7136\u540e\u8fdb\u884c\u795e\u7ecf\u808c\u8089\u963b\u6ede\u6cbb\u7597\u3001\u5438\u5165\u4e00\u6c27\u5316\u6c2e\uff08\u6d53\u5ea6\u4e3a 5-20 ppm\uff09\uff0c\u5e76\u901a\u8fc7\u63d2\u5165\u98df\u7ba1\u7403\u56ca\u63d0\u4f9b\u6700\u4f73\u547c\u6c14\u672b\u538b\u529b\u300273 74 <\/p>\n\n\n\n
\u5982\u679c\u51fa\u73b0\u4f11\u514b\u5e76\u4f34\u6709\u6025\u6027\u80be\u8870\u7aed\uff0c\u5219\u9700\u8981\u901a\u8fc7\u900f\u6790\u6765\u8fbe\u5230\u8d1f\u6db2\u4f53\u5e73\u8861\u3002\u6297\u83cc\u836f\u7269\u7528\u4e8e\u66b4\u9732\u524d\u548c\u66b4\u9732\u540e\u9884\u9632\u3002\u8fd9\u53ef\u4ee5\u9884\u9632SARS-CoV-2\u75be\u75c5\uff0c\u5e76\u964d\u4f4e\u7ee7\u53d1\u611f\u67d3\u7684\u98ce\u9669\u3002\u6db2\u4f53\u7ba1\u7406\u5bf9\u4e8e\u51cf\u5c11\u80ba\u6c34\u80bf\u81f3\u5173\u91cd\u8981\u300267 68 75 \u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9\u75c5\u6bd2\u6027\u80ba\u708e\u548c\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff08ARDS\uff09\u6709\u5bb3\uff0c\u56e0\u6b64\u6700\u597d\u907f\u514d\u4f7f\u7528\u300276\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u9759\u8109\u8f93\u6ce8\u7ef4\u751f\u7d20C\u8fdb\u884c\u62a2\u6551\u6cbb\u7597\u53ef\u4ee5\u51cf\u8f7b\u8113\u6bd2\u75c7\u548cARDS\u4e2d\u7684\u8840\u7ba1\u635f\u4f24\u548c\u5168\u8eab\u708e\u75c7\u300277<\/p>\n\n\n\n
\u75ab\u82d7\u7684\u4f5c\u7528<\/p>\n\n\n\n
COVID-19 \u75ab\u82d7\u7814\u53d1\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u4f46\u5b58\u5728\u8bf8\u591a\u5c40\u9650\u6027\u3002\u8fd9\u4e9b\u5c40\u9650\u6027\u5305\u62ec\uff1a(1) \u4e09\u671f\u75ab\u82d7\u8bd5\u9a8c\u5e94\u5728\u75be\u75c5\u6301\u7eed\u4f20\u64ad\u7684\u5730\u533a\u8fdb\u884c\uff1b(2) \u75ab\u82d7\u5236\u9020\u5546\u9700\u8981\u4e0e\u751f\u7269\u6280\u672f\u516c\u53f8\u5bc6\u5207\u5408\u4f5c\uff0c\u4ee5\u5f00\u53d1\u6709\u6548\u7684\u75ab\u82d7\uff0c\u8fd9\u53ef\u80fd\u81f3\u5c11\u9700\u8981 12-18 \u4e2a\u6708\uff1b(3) \u76d1\u7ba1\u673a\u6784\u5e94\u5728\u591a\u79cd\u52a8\u7269\u6a21\u578b\u4e2d\u8bc4\u4f30\u591a\u79cd\u75c5\u6bd2\u682a\u7684\u5b89\u5168\u6027\u300278\u201380<\/p>\n\n\n\n
\u76ee\u524d\uff0c\u8be5\u7814\u7a76\u75ab\u82d7\u5df2\u5229\u7528 mRNA \u4f5c\u4e3a\u57fa\u56e0\u5e73\u53f0\uff0c\u5e76\u501f\u9274\u4e86\u5148\u524d\u4e0e SARS \u548c MERS \u76f8\u5173\u7684\u7814\u7a76\u6210\u679c\u8fdb\u884c\u5f00\u53d1\u300216 24 \u6709\u6548\u75ab\u82d7\u7684\u57fa\u7840\u662f\u514d\u75ab\u9776\u5411\u6027\uff0c\u6d89\u53ca\u5728 120 \u4e2a\u53ef\u7528\u7684 SARS-CoV-2 \u57fa\u56e0\u5e8f\u5217\u4e2d\u8bc6\u522b\u6e90\u81ea\u523a\u7a81 (S) \u86cb\u767d\u548c\u6838\u8863\u58f3 (N) \u86cb\u767d\u7684 B \u7ec6\u80de\u548c T \u7ec6\u80de\u8868\u4f4d\u300224\u6709\u6548\u7684\u75ab\u82d7\u63a5\u79cd\u5c06\u5728\u51cf\u5c11\u75c5\u6bd2\u4f20\u64ad\u548c\u4ece\u5bbf\u4e3b\u4f53\u5185\u6e05\u9664\u75c5\u6bd2\u65b9\u9762\u53d1\u6325\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u300281<\/p>\n\n\n\n
\u7ed3\u8bba<\/p>\n\n\n\n
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